• Bracke KR, Dentener MA, Papakonstantinou E, Vernooy JH, Demoor T, Pauwels NS, Cleutjens J, van Suylen R, Joos GF, Brusselle GG, Wouters EF. Enhanced Deposition of Low Weight Hyaluronan in Lungs of Cigarette Smoke-Exposed Mice. Am J Respir Cell Mol Biol [Full text]

• Hommelberg PP, Langen RC, Schols AM, van Essen AL, Snepvangers FJ, Mensink RP, Plat J. Trans Fatty Acid-Induced NF-kappaB Activation Does Not Induce Insulin Resistance in Cultured Murine Skeletal Muscle Cells. Lipids [Full text]

• Loon J van, De Ruysscher D, Wanders R, Boersma L, Simons J, Oellers M, Dingemans AM, Hochstenbag M, Bootsma G, Geraedts W, Pitz C, Teule J, Rhami A, Thimister W, Snoep G, Dehing-Oberije C, Lambin P. Selective Nodal Irradiation on Basis of (18)FDG-PET Scans in Limited-Disease Small-Cell Lung Cancer: A Prospective Study. Int J Radiat Oncol Biol Phys [Full text]

• Muscaritoli M, Anker SD, Argilés J, Aversa Z, Bauer JM, Biolo G, Boirie Y, Bosaeus I, Cederholm T, Costelli P, Fearon KC, Laviano A, Maggio M, Fanelli FR, Schneider SM, Schols A, Sieber CC. Consensus definition of sarcopenia, cachexia and pre-cachexia: Joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics". Clin Nutr [Full text]

• Seymour JM, Spruit MA, Hopkinson NS, Sathyapala SA, Man WD, Jackson A, Gosker HR, Schols AM, Moxham J, Polkey MI, Wouters EF. The prevalence of quadriceps weakness in COPD and the relationship with disease severity. Eur Respir J [Full text]

• Van Berkel JJ, Dallinga JW, Möller GM, Godschalk RW, Moonen EJ, Wouters EF, Van Schooten FJ. A profile of volatile organic compounds in breath discriminates COPD patients from controls. Respir Med [Full text]

• Wijnen PA, Nelemans, PJ, Verschakelen, JA, Bekers, O, Voorter CE, Drent M. The role of tumor necrosis factor alpha G-308A polymorphisms in the course of pulmonary sarcoidosis. Tissue Antigens 2010; 75 Epub ahead of print

• Geraets L, Haegens A, Weseler AR, Brauers K, Vernooy JH, Wouters EF, Bast A, Hageman GJ. Inhibition of acute pulmonary and systemic inflammation by 1,7-dimethylxanthine. Eur J Pharmacol 2010;629:132-139

• Güngör N, Haegens A, Knaapen AM, Godschalk RW, Chiu RK, Wouters EF, van Schooten FJ. Lung inflammation is associated with reduced pulmonary nucleotide excision repair in vivo. Mutagenesis 2010 25:77-82

• Hoogendoorn M, van Wetering CR, Schols AM, Rutten-van Mölken MP. Is INTERdisicplinary COMmunity-based COPD management (INTERCOM) cost-effective? Eur Respir J 2010; 2010; 35: 79–87

• Loon J van, Grutters JP, Wanders R, Boersma L, Dingemans AM, Bootsma G, Geraedts W, Pitz C, Simons J, Brans B, Snoep G, Hochstenbag M, Lambin P, De Ruysscher D. (18)FDG-PET-CT in the follow-up of non-small cell lung cancer patients after radical radiotherapy with or without chemotherapy: An economic evaluation. Eur J Cancer 2010;46:110-119

• Remels AH, Langen RC, Schrauwen P, Schaart G, Schols AM, Gosker HR. Regulation of mitochondrial biogenesis during myogenesis. Mol Cell Endocrinol 2010;315:113–120

• Rutten EP, Spruit MA, Wouters EF. Critical view on diagnosing muscle wasting by single-frequency bio-electrical impedance in COPD. Respir Med 2010;104,91-98

• Schols AM. Body composition in COPD; stepping back or moving forward [editorial]? Respir Med 2010;104:157-158

• Wetering CR van, Hoogendoorn M, Broekhuizen R, Geraerts-Keeris GJ, De Munck DR, Rutten-van Mölken MP, Schols AM. Efficacy and Costs of Nutritional Rehabilitation in Muscle-Wasted Patients With Chronic Obstructive Pulmonary Disease in a Community-Based Setting: A Prespecified Subgroup Analysis of the INTERCOM Trial. J Am Med Dir Assoc 2010;11:179-187

• Wetering CR van, Hoogendoorn M, Mol SM, Rutten-van Mölken MP, Schols AM. Short- and long-term efficacy of a community-based COPD management program in less advanced COPD: a Randomized Controlled Trial. Thorax 2010;65:7-13

• Wijnen PA, Linssen CF, Haenen GR, Bekers O, Drent M. Variant VKORC1 and CYP2C9 Alleles in Patients with Diffuse Alveolar Hemorrhage Caused by Oral Anticoagulants. Mol Diagn Ther 2010;14:1-8

• Anathy V, Aesif SW, Guala AS, Havermans M, Reynaert NL, Ho YS, Budd RC, Janssen-Heininger YM. Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas. J Cell Biol 2009;184:241-52.

• Anker SD, Laviano A, Filippatos G, John M, Paccagnella A, Ponikowski P, Schols AM; ESPEN. ESPEN Guidelines on Parenteral Nutrition: on cardiology and pneumology. Clin Nutr 2009;28:455-60

• Breyer MK, Spruit MA, Celis AP, Rutten EP, Janssen PP, Wouters EF; On behalf of the CIRO Network. Highly elevated C-reactive protein levels in obese patients with COPD: A fat chance? Clin Nutr 2009;28:642–647

• Baughman RP, Shipley R, Desai S, Drent M, Judson MA, Costabel U, du Bois RM, Kavuru M, Schlenker-Herceg R, Flavin S, Lo KH, Barnathan ES. Changes in Chest Roentgenogram of Sarcoidosis Patients During a Clinical Trial of Infliximab Therapy: Comparison of Different Methods of Evaluation. Chest 2009;136:526–535.

• Boots AW, Drent M, Swennen EL, Moonen HJ, Bast A, Haenen GR. Antioxidant status associated with inflammation in sarcoidosis: A potential role for antioxidants. Respir Med 2009;103:364-372

• Dallinga JW, Robroeks CM, van Berkel JJ, Moonen EJ, Godschalk RW, Jöbsis Q, Dompeling E, Wouters EF, van Schooten FJ. Volatile organic compounds in exhaled breath as a diagnostic tool for asthma in children. Clin Exp Allergy 2009;40:68–76

• Effing TW, Kerstjens HA, Monninkhof EM, van der Valk PD, Wouters EF, Postma DS, Zielhuis GA, van der Palen J. Definitions of exacerbations: does it really matter in clinical trials on COPD [commentary]? Chest 2009;136:918-23.

• Geraets L, Haegens A, Brauers K, Haydock JA, Vernooy JH, Wouters EF, Bast A, Hageman GJ. Inhibition of LPS-induced pulmonary inflammation by specific flavonoids. Biochem Biophys Res Commun 2009;382:598-603

• Gosker HR, Langen RC, Bracke KR, Joos GF, Brusselle GG, Steele C, Ward KA, Wouters EF, Schols AM. Extrapulmonary manifestations of COPD in a mouse model of chronic cigarette smoke exposure. Am J Respir Cell Mol Biol 2009;40:710–716.

• Graat-Verboom L, Spruit MA, van den Borne BE, Smeenk FW, Martens EJ, Lunde R, Wouters EF; On behalf of the CIRO Network. Correlates of osteoporosis in chronic obstructive pulmonary disease: An underestimated systemic component. Respir Med 2009;103:1143-51

• Graat-Verboom L, Wouters EF, Smeenk FW, van den Borne BE, Lunde R, Spruit MA. Current status of research on osteoporosis in COPD: a systematic review. Eur Respir J 2009;34:209-18.

• Haegens A, Heeringa P, van Suylen RJ, Steele C, Aratani Y, O'Donoghue RJ, Mutsaers SE, Mossman BT, Wouters EF, Vernooy JH. Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production. J Immunol 2009;182:7990-6.

• Hommelberg PP, Plat J, Langen R, Schols AM, Mensink RP. Fatty acid induced NF-{kappa}B activation and insulin resistance in skeletal muscle are chain length dependent. Am J Physiol Endocrinol Metab 2009; 296: E114–E120.

• Hoogendoorn M, van Wetering CR, Schols AM, Rutten-van Mölken MP. Self-report versus care provider registration of healthcare utilization: impact on cost and cost-utility. Int J Technol Assess Health Care 2009;25:588-95.

• Houben JM, Mercken EM, Ketelslegers HB, Bast A, Wouters EF, Hageman GJ, Schols AM. Telomere shortening in chronic obstructive pulmonary disease. Respir Med 2009;103:230-236

• Kleijn WPE de, De Vries J, Lowerd EE, Elfferich MDP, Baughmand RP, Drent M. Fatigue in sarcoidosis: a systematic review. Curr Opin Pulm Med 2009; 15:499–506.

• Kleijn WPE de, Elfferich MDP, De Vries J, Jonker GJ, Lower EE, Baughman RP, King Jr. TE, Drent M. Fatigue in sarcoidosis: American versus Dutch patients. Sarcoidosis Vasc Diffuse Lung Dis 2009; 26; 92-97

• Kotz D, Huibers MJ, West RJ, Wesseling G, van Schayck OC. What mediates the effect of confrontational counselling on smoking cessation in smokers with COPD? Patient Educ Couns 2009; 76:16-24

• Kotz D, Wesseling G,Huibers MJ, van Schayck OC. Efficacy of confronting smokers with airflow limitation for smoking cessation. Eur Respir J 2009;33:754-762

• Loon J van, Grutters J, Wanders R, Boersma L, Oellers M, Dingemans AM, Bootsma G, Geraedts W, Pitz C, Simons J, Fatah SA, Snoep G, Hochstenbag M, Lambin P, De Ruysscher D. Follow-up with (18)FDG-PET-CT after radical radiotherapy with or without chemotherapy allows the detection of potentially curable progressive disease in non-small cell lung cancer patients: A prospective study. Eur J Cancer 2009;45:588-595

• Maas T, Kaper J, Sheikh A, Knottnerus JA, Wesseling G, Dompeling E, Muris JW, van Schayck CP. Mono and multifaceted inhalant and/or food allergen reduction interventions for preventing asthma in children at high risk of developing asthma. Cochrane Database Syst Rev 2009;8:CD006480

• Mercken EM, Calvert LD, Singh SJ, Hageman GJ, Schols AM, Steiner MC. Dichloroacetate Modulates the Oxidative Stress and Inflammatory Response to Exercise in COPD. Chest 2009 136:744-751

• Mercken EM, Gosker HR, Rutten EP, Wouters EF, Bast A, Hageman GJ, Schols AM. Systemic and Pulmonary Oxidative Stress After Single-Leg Exercise in COPD. Chest 2009 136:1291-1300

• Op den Kamp CM, Langen RC, Haegens A, Schols AM. Muscle atrophy in cachexia: can dietary protein tip the balance? Curr Opin Clin Nutr Metab Care 2009;12:611–616

• Oudhuis GJ, Beuving J, Bergmans D, Stobberingh EE, Ten Velde G, Linssen CF, Verbon A. Soluble Triggering Receptor Expressed on Myeloid cells-1 in bronchoalveolar lavage fluid is not predictive for ventilator-associated pneumonia. Intensive Care Med 2009;35:1265–1270.

• Palmen M, van Breugel HN, Geskes GG, van Belle A, Swennen JM, Drijkoningen AH, van der Hulst RR, Maessen JG. Open window thoracostomy treatment of empyema is accelerated by vacuum-assisted closure. Ann Thorac Surg 2009;88:1131-6.

• Pillai SG, Ge D, Zhu G, Kong X, Shianna KV, Need AC, Feng S, Hersh CP, Bakke P, Gulsvik A, Ruppert A, Lødrup Carlsen KC, Roses A, Anderson W, Rennard SI, Lomas DA, Silverman EK, Goldstein DB; ICGN Investigators including Wouters EF. A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet 200;5;e1000421

• Pitta F, Breyer MK, Hernandes NA, Teixeira D, Sant'anna TJ, Fontana AD, Probst VS, Brunetto AF, Spruit MA, Wouters EF, Burghuber OC, Hartl S. Comparison of daily physical activity between COPD patients from Central Europe and South America. Respir Med 2009;103:421-426

• Remels AH, Langen RC, Gosker HR, Russell AP, Spaapen F, Voncken JW, Schrauwen P, Schols AM. PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle. Am J Physiol Endocrinol Metab 2009;297:E174-83

• Ruysscher D De, Botterweck A, Dirx M, Pijls-Johannesma M, Wanders R, Hochstenbag M, Dingemans AM, Bootsma G, Geraedts W, Simons J, Pitz C, Lambin P. Eligibility for concurrent chemotherapy and radiotherapy of locally advanced lung cancer patients: a prospective, population-based study. Ann Oncol 2009;20:98–102

• Ruysscher D De, Dehing C, Bentzen SM, Houben R, Dekker A, Wanders R, Borger J, Hochstenbag M, Boersma L, Geskes G, Dingemans AM, Bootsma G, Lammering G, Lambin P. n we optimize chemo-radiation and surgery in locally advanced stage III non-small cell lung cancer based on evidence from randomized clinical trials? A hypothesis-generating study. Radiother Oncol 2009;93:389–395

• Ruysscher D De, Dehing C, Yu S, Wanders R, Ollers M, Dingemans AM, Bootsma G, Hochstenbag M, Geraedts W, Pitz C, Simons J, Boersma L, Borger J, Dekker A, Lambin P. Dyspnea evolution after high-dose radiotherapy in patients with non-small cell lung cancer. Radiother Oncol 2009;91:353–359

• Ruysscher D De, Houben A, Aerts HJ, Dehing C, Wanders R, Ollers M, Dingemans AM, Hochstenbag M, Boersma L, Borger J, Dekker A, Lambin P. Increased (18)F-deoxyglucose uptake in the lung during the first weeks of radiotherapy is correlated with subsequent Radiation-Induced Lung Toxicity (RILT): A prospective pilot study. Radiother Oncol 2009;91:415–420.

• Schayck CP van, Kaper J, Wagena EJ, Wouters EF, Severens JL. The cost-effectiveness of antidepressants for smoking cessation in chronic obstructive pulmonary disease (COPD) patients. Addiction 2009;104:2110-7.

• Schermer T, Chavannes N, Dekhuijzen R, Wouters E, Muris J, Akkermans R, van Schayck O, van Weel C. Fluticasone and N-acetylcysteine in primary care patients with COPD or chronic bronchitis. Respir Med 2009;103:542-51.

• Schols AM. Nutritional rehabilitation: from pulmonary cachexia to sarcoPD [editorial]. Eur Respir J. 2009;33:949-50.

• Sillen MJ, Speksnijder CM, Eterman RM, Janssen PP, Wagers SS, Wouters EF, Uszko-Lencer NH, Spruit MA. Effects of Neuromuscular Electrical Stimulation of Muscles of Ambulation in Patients With Chronic Heart Failure or COPD: A Systematic Review of the English-Language Literature. Chest 2009;136:44-61

• Soeters PB, Schols AM. Advances in understanding and assessing malnutrition. Curr Opin Clin Nutr Metab Care 2009;12:487-94.

• Spruit MA, Eterman RM, Hellwig V, Janssen P, Wouters E, Uszko-Lencer N. Effects of moderate-to-high intensity resistance training in patients with chronic heart failure. Heart 2009;95:1399-1408

• Spruit MA, Janssen DJ, Franssen FM, Wouters EF. Rehabilitation and palliative care in lung fibrosis. Respirology 2009;14:781-7.

• Swallow EB, Barreiro E, Gosker H, Sathyapala SA, Sanchez F, Hopkinson NS, Moxham J, Schols A, Gea J, Polkey MI; on behalf on the ENIGMA in COPD project. Quadriceps muscle strength in scoliosis. Eur Respir J 2009;34:1429-1435.

• Vanfleteren LE, Peulen HM, Creytens DH, Smulders NM, Utama I, de Ruysscher DK, ten Velde GP. Complete metabolic remission of an irresectable mediastinal solitary fibrous tumour with concurrent chemoradiation [Case report]. Thorax 2009;64:822-3.

• Vernooy JH, Drummen NE, Van Suylen RJ, Cloots RH, Moller GM, Bracke KR, Zuyderduyn S, Dentener MA, Brusselle GG, Hiemstra PS, Wouters EF. Enhanced pulmonary leptin expression in patients with severe COPD and asymptomatic smokers. Thorax 2009;64:26-32

• Weseler AR, Geraets L, Moonen HJ, Manders RJ, van Loon LJ, Pennings HJ, Wouters EF, Bast A, Hageman GJ. Poly (ADP-ribose) Polymerase-1-Inhibiting Flavonoids Attenuate Cytokine Release in Blood from Male Patients with Chronic Obstructive Pulmonary Disease or Type 2 Diabetes. J Nutr 2009;139:952–957

• Willems DC, Joore MA, Nieman FH, Severens JL, Wouters EF, Hendriks JJ. Using EQ-5D in children with asthma, rheumatic disorders, diabetes, and speech/language and/or hearing disorders. Int J Technol Assess Health Care 2009;25:391-9.

• Wijnen PA, Drent M, van Dieijen-Visser MP, Bekers O. Pharmacogenetic testing after a simple DNA isolation method on buccal swab samples. Pharmacogen 2009;10:983-987.

• Wijnen PA, Limantoro I, Drent M,Bekers O, Kuijpers PM, Koek GH. Depressive effect of an antidepressant: therapeutic failure of venlafaxine in a case lacking CYP2D6 activity. Ann Clin Biochem 2009; 46: 527–530.

• Wouters EF, Vanderhoven IM. Pulmonary rehabilitation and integrated care. Semin Respir Crit Care Med 2009;30:713-20

• Yanbaeva DG, Dentener MA, Spruit MA, Houwing-Duistermaat JJ, Kotz D, Lima Passos V, Wouters EF. IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study. BMC Med Genet 2009;10:23

• Yanbaeva DG, Wouters EF, Dentener MA, Spruit MA, Reynaert NL. Association of glutathione-S-transferase omega haplotypes with susceptibility to chronic obstructive pulmonary disease. Free Radic Res 2009;43:738 - 743

2008

• Baardwijk A van, Bosmans G, Boersma L, Wanders S, Dekker A, Dingemans AM, Bootsma G, Geraedts W, Pitz C, Simons J, Lambin P, De Ruysscher D. Individualized radical radiotherapy of non-small-cell lung cancer based on normal tissue dose constraints: a feasibility study. Int J Radiat Oncol Biol Phys. 2008;71:1394-401.

• Baardwijk A van, Bosmans G, van Suylen RJ, van Kroonenburgh M, Hochstenbag M, Geskes G, Lambin P, De Ruysscher D. Correlation of intra-tumour heterogeneity on (18)F-FDG PET with pathologic features in non-small cell lung cancer: A feasibility study. Radiother Oncol 2008;87:55-58

• Barreiro E, Schols AM, Polkey MI, Galdiz JB, Gosker HR, Swallow EB, Coronell C, Gea J. Cytokine profile in quadriceps muscles of patients with severe chronic obstructive pulmonary disease. Thorax 2008:63:100-107

• Baughman RP, Lower EE, Drent M. Inhibitors of Tumor Necrosis Factor (TNF) in Sarcoidosis: Who, What, and How to Use Them. Sarcoidosis Vasc Diffuse Lung Dis 2008; 25; 76-89.

• Berkel JJ Van, Dallinga JW, Möller GM, Godschalk RW, Moonen E, Wouters EF, Van Schooten FJ. Development of accurate classification method based on the analysis of volatile organic compounds from human exhaled air.J Chromatogr B Analyt Technol Biomed Life Sci 2008;861:100-107

• Brink KI van den, Boorsma M, Staal-van den Brekel AJ, Edsbäcker S, Wouters EF, Thorsson L. Evidence of the in vivo esterification of budesonide in human airways. Br J Clin Pharmacol 2008;66:27-35

• Cazzola M, MacNee W, Martinez FJ, Rabe KF, Franciosi LG, Barnes PJ, Brusasco V, Burge PS, Calverley PM, Celli BR, Jones PW, Mahler DA, Make B, Miravitlles M, Page CP, Palange P, Parr D, Pistolesi M, Rennard SI, Rutten-van Mölken MP, Stockley R, Sullivan SD, Wedzicha JA, Wouters EF; ATS; ERS Task Force on outcomes of COPD. Outcomes for COPD pharmacological trials: from lung function to biomarkers. Eur Respir J 2008;31:416-69.

• Dehing-Oberije C, De Ruysscher D, van der Weide H, Hochstenbag M, Bootsma G, Geraedts W, Pitz C, Simons J, Teule J, Rahmy A, Thimister P, Steck H, Lambin P. Tumor volume combined with number of positive lymph node stations is a more important prognostic factor than TNM stage for survival of non-small-cell lung cancer patients treated with (chemo)radiotherapy. Int J Radiat Oncol Biol Phys 2008;70:1039-1044

• Dentener MA, Creutzberg EC, Pennings HJ, Rijkers GT, Mercken E, Wouters EF. Effect of Infliximab on Local and Systemic Inflammation in Chronic Obstructive Pulmonary Disease: A Pilot Study. Respiration 2008;76:275–282

• Derom E, van Weel C, Liistro G, Buffels J, Schermer T, Lammers E, Wouters E, Decramer M. Primary care spirometry. Eur Respir J 2008;31:197-203.

• Evans WJ, Morley JE, Argilés J, Bales C, Baracos V, Guttridge D, Jatoi A, Kalantar-Zadeh K, Lochs H, Mantovani G, Marks D, Mitch WE, Muscaritoli M, Najand A, Ponikowski P, Rossi Fanelli F, Schambelan M, Schols A, Schuster M, Thomas D, Wolfe R, Anker SD. Cachexia: A new definition. Clin Nutr 2008;27:793-799.

• Franssen FM, O'Donnell DE, Goossens GH, Blaak EE, Schols AM. Obesity and the lung: 5 · Obesity and COPD. Thorax 2008;63:1110-1117.

• Franssen FM, Sauerwein HP, Rutten EP, Wouters EF, Schols AM. Whole body resting and exercise-induced lipolysis in sarcopaenic patients with COPD. Eur Respir J 2008; 32: 1466 - 1471

• Gosker HR, Schols AM. Fatigued muscles in COPD but no finishing line in sight [editorial]. Eur Respir J 2008;31: 693–694.

• Groenewegen KH, Postma DS, Hop WC, Wielders PL, Schlösser NJ, Wouters EF; for the COSMIC Study Group. Increased Systemic Inflammation Is a Risk Factor for COPD Exacerbations. Chest 2008;133:350-357

• Haegens A, Vernooy JH, Heeringa P, Mossman BT, Wouters EF. Myeloperoxidase modulates lung epithelial responses to pro-inflammatory agents. Eur Respir J 2008;31:252-260

• Heijckmann AC, Drent M, Dumitrescu B, De Vries J, Nieuwenhuijzen Kruseman AC, Wolffenbuttel BH, Geusens P, Huijberts MS. Progressive vertebral deformities despite unchanged bone mineral density in patients with sarcoidosis: a 4-year follow-up study. Osteoporos Int 2008;19:839–847

• Heijckmann AC, Dumitrescu B, Nieuwenhuijzen Kruseman AC, Geusens P, Wolffenbuttel BH, De Vries J, Drent M, Huijberts MS. Quantitative ultrasound does not identify patients with an inflammatory disease at risk of vertebral deformities.BMC Musculoskelet Disord 2008;9:72.

• Janssen DJ, Alsemgeest TP, Widdershoven GA, Wouters EF, Schols JM, Spruit MA. The last wish of a patient with end stage chronic obstructive pulmonary disease. BMJ 2008;337:a2701

• Janssen DJ, Spruit MA, Wouters EF, Schols JM. Daily symptom burden in end-stage chronic organ failure: a systematic review. Palliat Med 2008;22:938-48

• Jonker GJ, Smulders NM, van Kroonenburgh MJ, Halders S, de Vries J, Faber CG, Drent M. Lung-uptake and -washout of MIBG in sarcoidosis. Respir Med 2008; 102:64-70

• Judson MA, Baughman RP, Costabel U, Flavin S, Lo KH, Kavuru MS, Drent M; the Centocor T48 investigators. Efficacy of Infliximab in Extrapulmonary Sarcoidosis: Results from a Randomized Trial. Eur Respir J 2008;31:1189–1196

• Kakarlapudi N, Vernooy JH, Quan L, Fijneman RJ, Demant P. Control of lymphocyte infiltration of lung tumors in mice by host's genes: mapping of four Lynf (lymphocyte infiltration) loci. Cancer Immunol Immunother 2008;57:217-25.

• Kotz D, Huibers MJ, Vos R, van Schayck CP, Wesseling G. Principles of confrontational counselling in smokers with chronic obstructive pulmonary disease (COPD). Med Hypotheses 2008;70:384-386

• Kotz D, van Litsenburg W, van Duurling R, van Schayck CP, Wesseling GJ. Smoking cessation treatment by Dutch respiratory nurses: Reported practice, attitudes and perceived effectiveness. Patient Educ Couns 2008;70:40-49

• Kotz D, Nelemans P, van Schayck CP, Wesseling GJ. External validation of a chronic obstructive pulmonary disease diagnostic questionnaire. Eur Respir J 2008;31:298-303

• LeVan TD, Michel O, Dentener M, Thorn J, Vertongen F, Beijer L, Martinez FD. Association between CD14 polymorphisms and serum soluble CD14 levels: Effect of atopy and endotoxin inhalation. J Allergy Clin Immunol 2008;121:434-440

• Linssen CF, Bekers O, Drent M, Jacobs JA. C-reactive protein and procalcitonin concentrations in bronchoalveolar lavage fluid as a predictor of ventilator-associated pneumonia. Ann Clin Biochem. 2008;45:293-8.

• Linssen CF, Jacobs JA, Schouten JS, van Mook WN, Ramsay G, Drent M. Influence of antibiotic therapy on the cytological diagnosis of ventilator-associated pneumonia. Intensive Care Med 2008;34:865–872

• Linssen CF, Jacobs JA, Stelma FF, van Mook WN, Terporten P, Vink C, Drent M, Bruggeman CA, Smismans A. Herpes simplex virus load in bronchoalveolar lavage fluid is related to poor outcome in critically ill patients. Intensive Care Med 2008;34:2202–2209

• Lomas DA, Silverman EK, Edwards LD, Miller BE, Coxson HO, Tal-Singer R, and the ECLIPSE investigators including Wouters EFM. Evaluation of serum CC-16 as a biomarker for chronic obstructive pulmonary disease in the ECLIPSE cohort. Thorax 2008;63:1058-1063

• Loon JV, Offermann C, Bosmans G, Wanders R, Dekker A, Borger J, Oellers M, Dingemans AM, Baardwijk AV, Teule J, Snoep G, Hochstenbag M, Houben R, Lambin P, Ruysscher DD. (18)FDG-PET based radiation planning of mediastinal lymph nodes in limited disease small cell lung cancer changes radiotherapy fields: A planning study. Radiother Oncol 2008;87:49–54

• Remels AH, Gosker HR, Schrauwen P, Langen RC, Schols AM. Peroxisome proliferator-activated receptors: a therapeutic target in COPD? Eur Respir J 2008;31:502-8.

• Rutten EP, Engelen MP, Gosker H, Bast A, Cosemans K, Vissers YL, Wouters EF, Deutz NE, Schols AM. Metabolic and functional effects of glutamate intake in patients with chronic obstructive pulmonary disease (COPD). Clin Nutr 2008;27:408-415

• Saltini C, Pallante M, Puxeddu E, Contini S, Voorter CE, Drent M, Amicosante M. M. aviumbinding to HLA-DR expressed alleles in silico: amodel of phenotypic susceptibility to sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2008; 25; 100-116.

• Seute T, Leffers P, Ten Velde GP, Twijnstra A.Detection of brain metastases from small cell lung cancer: consequences of changing imaging techniques (CT versus MRI). Cancer 2008; 112:1827-1834

• Sillen MJ, Janssen PP, Akkermans MA, Wouters EF, Spruit MA. The metabolic response during resistance training and neuromuscular electrical stimulation (NMES) in patients with COPD, a pilot study. Respir Med 2008;102:786-789

• Smulders NM, Bast A., van Kroonenburgh MJPG, Drent M. Improvement of cardiac sympathetic nerve function in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2008; 25; 140-142.

• Spruit MA, Vanderhoven-Augustin I, Janssen PP, Wouters EFM. Integration of pulmonary rehabilitation in COPD. Lancet 2008; 371;12-13

• Thomeer M, Demedts M, Behr J, Buhl R, Costabel U, Flower CDR, Verschakelen J, Laurent F, Nicholson AG, Verbeken EK, Capron F, Sardina M, Corvasce G, Lankhorst I, the IFIGENIA study group including M. Drent. Accuracy of diagnosis of idiopathic pulmonary fibrosis. Eur Respir J 2008; 31: 585-91

• Patel BD, Coxson HO, Pillai SG, Agusti AG, Calverley PM, Donner CF, Make BJ, Muller NL, Rennard SI, Vestbo J, Wouters EF, Hiorns MP, Nakano Y, Camp PG, Nasute Fauerbach PV, Screaton NJ, Campbell EJ, Anderson WH, Silverman EK, Lomas DA. Airway Wall Thickening and Emphysema Show Independent Familial Aggregation in COPD. Am J Respir Crit Care Med 2008;178:500-505

• Pauwels R, Joos GF, Fogarty C, Faiferman I, Hirschberg S, Vessey R, Wouters EF.Bronchodilating effect of combined therapy with ipratropium bromide and ondansetron in patients with COPD. Pulm Pharmacol Ther 2008;21;385-392

• De Ruysscher D, Wanders R, van Haren E, Hochstenbag M, Geraedts W, Pitz C, Simons J, Boersma L, Verschueren T, Minken A, Bentzen SM, Lambin P.HI-CHART: A Phase I/II Study on the Feasibility of High-Dose Continuous Hyperfractionated Accelerated Radiotherapy in Patients with Inoperable Non-Small-Cell Lung Cancer. Int J Radiat Oncol Biol Phys 2008;71:132-138

• Velden JL van der, Schols AM, Willems J, Kelders MC, Langen RC. GSK-3beta suppresses myogenic differentiation through negative regulation of NFATc3. J Biol Chem 2008;283:358-366

• Vestbo J, Anderson W, Coxson HO, Crim C, Dawber F, Edwards L, Hagan G, Knobil K, Lomas DA, MacNee W, Silverman EK, Tal-Singer R, the ECLIPSE investigators including Wouters EFM. Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE). Eur Respir J 2008;31:869–873
• Vries J De, Drent M. Quality of life and health status in sarcoidosis: a review. Clin Chest Med 2008;29:525-532.

• Wijnen PA, Op den Buijsch RA, Cheung SC, van der Heijden J, Hoogtanders K, Stolk LM, van Dieijen-Visser MP, Neef C, Drent M, Bekers O.Genotyping with a dried blood spot method: A useful technique for application in pharmacogenetics. Clin Chim Acta 2008;388:189–191

• Willems DMC, Joore MA, Hendriks JJE, Nieman FHN, Severens JL, Wouters EFM. The effectiveness of nurse-led telemonitoring of asthma: results of a randomized controlled trial. J Eval Clin Pract 2008;14:600–609

• Wijnen PA, Drent M, Nelemans PJ, Kuijpers PM, Koek GH, Neef C, Haenen GR and Bekers O. Role of Cytochrome P450 Polymorphisms in the Development of Pulmonary Drug Toxicity. A Case-Control Study in the Netherlands. Drug Safety 2008;31:1125-1134

2007

• Bakker JA, Drent M, Bierau J. Relevance of pharmacogenetic aspects of mercaptopurine metabolism in the treatment of interstitial lung disease. Curr Opin Pulm Med 2007;13:458–463

• Bakker JA, Bierau J, Drent M.Therapeutic regimens in interstitial lung disease guided by genetic screening: fact or fiction? [editorial] Eur Respir J 2007;30:821-2

• Baardwijk A van, Bosmans G, Boersma L, Buijsen J, Wanders S, Hochstenbag M, van Suylen RJ, Dekker A, Dehing-Oberije C, Houben R, Bentzen SM, van Kroonenburgh M, Lambin P, De Ruysscher D. PET-CT-based auto-contouring in non-small-cell lung cancer correlates with pathology and reduces interobserver variability in the delineation of the primary tumor and involved nodal volumes. Int J Radiat Oncol Biol Phys 2007;68:771-8

• Baardwijk A van, Dooms C, van Suylen RJ, Verbeken E, Hochstenbag M, Dehing-Oberije C, Rupa D, Pastorekova S, Stroobants S, Buell U, Lambin P, Vansteenkiste J, Ruysscher DD. The maximum uptake of (18)F-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor-1alpha and GLUT-1 in non-small cell lung cancer. Eur J Cancer 2007;43:1392-8.

• Bemt L van den, De Vries MP, Cloosterman S, Thoonen B, Muris JWM, Goossens M, Wesseling G, Van Schayck CP. Influence of House Dust Mite Impermeable Covers on Health-Related Quality of Life of Adult Patients with Asthma: Results of a Randomized Clinical Trial. J Asthma, 2007; 44:843–848

• Bolton CE, Broekhuizen R, Ionescu AA, Nixon LS, Wouters EF, Shale DJ, Schols AM. Cellular Protein Breakdown and Systemic Inflammation are Unaffected by Pulmonary Rehabilitation in COPD. Thorax 2007;62:109- 114.

• Bons JA, Drent M, Bouwman FG, Mariman EC, van Dieijen-Visser MP, Wodzig WK. Potential biomarkers for diagnosis of sarcoidosis using proteomics in serum. Respir Med 2007;101:1687-1695

• Drent m, Mansour K, Linssen C. Bronchoalveolar Lavage in Sarcoidosis. Semin Respir Crit Care Med 2007;28:486-495

• Engelen MP, Rutten EP, De Castro CL, Wouters EF, Schols AM, Deutz NE. Supplementation of soy protein with branched-chain amino acids alters protein metabolism in healthy elderly and even more in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 2007;85:431-9.

• Geraets L, Moonen HJ, Brauers K, Wouters EF, Bast A, Hageman GJ. Dietary Flavones and Flavonoles Are Inhibitors of Poly(ADP-ribose)polymerase-1 in Pulmonary Epithelial Cells. J Nutr 2007;137:2190-2195.

• Geraets L, Moonen HJ, Brauers K, Gottschalk RW, Wouters EF, Bast A, Hageman GJ. Flavone as PARP-1 inhibitor: Its effect on lipopolysaccharide induced gene-expression. Eur J Pharmacol 2007;573:241–248

• Groenewegen KH, Dentener MA, Wouters EF. Longitudinal follow-up of systemic inflammation after acute exacerbations of COPD. Respir Med 2007;101:2409–2415

• Gosker HR, Hesselink MK, Duimel H, Ward KA, Schols AM. Reduced mitochondrial density in the vastus lateralis muscle of patients with COPD. Eur Respir J 2007;30:73-79

• Gosker HR, Schols AM. Muscle Metabolic Modulation by Chronic Hypoxia. J Proteome Res 2007;6:3400-3401

• Gosker HR, Zeegers M, Wouters FM, Schols AMWJ. Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysis. Thorax 2007;62:944–949

• Ham EC van den, Kooman JP, Schols AM, Nieman FH, Does JD, Akkermans MA, Janssen PP, Gosker HR, Ward KA, Macdonald JH, Christiaans MH, Leunissen KM, van Hooff JP. The Functional, Metabolic, and Anabolic Responses to Exercise Training in Renal Transplant and Hemodialysis Patients. Transplantation 2007;83:1059-1068.

• Heijckmann C, Huijberts MSP, De Vries J, Menheere PPCA, Van Der Veer E, Nieuwenhuijzen Kruseman AC, Wolffenbuttel BHR, Geusens P, Drent M. Bone turnover and hip bone mineral density in patients with sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2007;24:51-58

• Kotz D, Wagena EJ, Wesseling G. Smoking cessation practices of Dutch general practitioners, cardiologists, and lung physicians. Respir Med 2006

• Kotz D, Wesseling G, Huibers MJ, van Schayck OC.Efficacy of confrontational counselling for smoking cessation in smokers with previously undiagnosed mild to moderate airflow limitation: study protocol of a randomized controlled trial. BMC Public Health 2007;7;332

• Kuiper S, Muris JW, Dompeling E, Kester AD, Wesseling G, Knottnerus JA, van Schayck CP. Interactive effect of family history and environmental factors on respiratory tract-related morbidity in infancy. J Allergy Clin Immunol 2007;120:388-95

• Langen RC, Schols AM. Inflammation: friend or foe of muscle remodelling in COPD? [editorial] Eur Respir J 2007;30:605-7.

• Luijendijk SC, Ijzerman TH, van der Grinten CP. Oxygen isotope fractionation in healthy subjects and in patients with COPD. Respir Physiol Neurobiol 2007;157:335–340

• Michel O, Dentener M, Cataldo D, Cantinieaux B, Vertongen F, Delvaux C, Murdoch RD. Evaluation of oral corticosteroids and phosphodiesterase-4 inhibitor on the acute inflammation induced by inhaled lipopolysaccharide in human. Pulm Pharmacol Ther 2007;20:676-83

• Michielsen HJ, Peros-Golubicic T, Drent M, De Vries J. Relationship between Symptoms and Quality of Life in a Sarcoidosis Population. Respiration 2007;74:401–405

• Palange P, Ward SA, Carlsen KH, Casaburi R, Gallagher CG, Gosselink R, O'Donnell DE, Puente-Maestu L, Schols AM, Singh S, Whipp BJ. Recommendations on the use of exercise testing in clinical practice. Eur Respir J 2007;29:185-209.

• Remels AH, Gosker HR, van der Velden J, Langen RC, Schols AM. Systemic inflammation and skeletal muscle dysfunction in chronic obstructive pulmonary disease: state of the art and novel insights in regulation of muscle plasticity. Clin Chest Med 2007;28:537-52.

• Remels AH, Schrauwen P, Broekhuizen R, Willems J, Kersten S, Gosker HR, Schols AM. Expression and content of PPARs is reduced in skeletal muscle of COPD patients. Eur Respir J 2007;30:245-252

• Reynaert NL, Aesif SW, McGovern T, Brown A, Wouters EF, Irvin CG, Janssen-Heininger YM. Catalase overexpression fails to attenuate allergic airways disease in the mouse. J Immunol 2007;178:3814-21.

• Reynaert NL, Wouters EF, Janssen-Heininger YM. Modulation of Glutaredoxin-1 Expression in a Mouse Model of Allergic Airway Disease. Am J Respir Cell Mol Biol 2007;36:147–151.

• Robroeks CM, van de Kant KD, Jobsis Q, Hendriks HJ, van Gent R, Wouters EF, Damoiseaux JG, Bast A, Wodzig WK, Dompeling E. Exhaled nitric oxide and biomarkers in exhaled breath condensate indicate the presence, severity and control of childhood asthma. Clin Exp Allergy 2007;37:1303-11.

• Ruysscher D De, Dehing C, Bremer RH, Bentzen S, Koppe F, Pijls-Johannesma M, Harzee L, Minken A, Wanders R, Hochstenbag M, Dingemans AM, Boersma L, van Haren E, Geraedts W, Pitz C, Simons J, Wouters B, Rosier JF, Lambin P. Maximal neutropenia during chemotherapy and radiotherapy is significantly associated with the development of acute radiation-induced dysphagia in lung cancer patients. Ann Oncol 2007;18:909-916.

• Schans VA van de, van den Borne SW, Strzelecka AE, Janssen BJ, van der Velden JL, Langen RC, Wynshaw-Boris A, Smits JF, Blankesteijn WM. Interruption of Wnt signaling attenuates the onset of pressure overload-induced cardiac hypertrophy. Hypertension. 2007;49:473-80.

• Scharloo M, Kaptein AA, Schlosser M, Pouwels H, Bel EH, Rabe KF, Wouters EF. Illness perceptions and quality of life in patients with chronic obstructive pulmonary disease. J Asthma 2007;44:575-81

• Spruit MA, Pennings HJ, Janssen PP, Does JD, Scroyen S, Akkermans MA, Mostert R, Wouters EF. Extra-pulmonary features in COPD patients entering rehabilitation after stratification for MRC dyspnea grade. Respir Med 2007;101:2454–2463

• Spruit MA, Wouters EF. New modalities of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease. Sports Med. 2007;37:501-18.

• Swallow EB, Gosker HR, Ward KA, Moore AJ, Dayer MJ, Hopkinson NS, Schols AMWJ, Moxham J, Polkey MI. A novel technique for non-volitional assessment of quadriceps muscle endurance in man. J Appl Physiol 2007;103:739-746.

• Velden J van der, Langen R, Kelders M, Willems J, Wouters E, Janssen-Heininger Y, Schols A. Myogenic differentiation during regrowth of atrophied skeletal muscle is associated with inactivation of GSK-3{beta} Am J Physiol Cell Physiol. 2007;292:C1636-C1644.

• Veltkamp M, Wijnen PA, van Moorsel CH, Rijkers GT, Ruven HJ, Heron M, Bekers O, Claessen AM, Drent M, van den Bosch JM, Grutters JC. Linkage between Toll-like receptor (TLR) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis.Clin Exp Immunol 2007;149:453–462

• Vernooy JH, Moller GM, V Suylen RJ, van Spijk MP, Cloots RH, Hoet PH, Pennings HJ, Wouters EF. Increased Granzyme A Expression In Type II Pneumocytes of Patients With Severe COPD. Am J Respir Crit Care Med 2007;175:464–472.

• Voorter CE, Amicosante M, Berretta F, Groeneveld L, Drent M, van den Berg-Loonen EM. HLA class II amino acid epitopes as susceptibility markers of sarcoidosis. Tissue Antigens 2007;70:18-27.

• Vries J De, Drent M. Quality of life and health status in sarcoidosis: a review. Semin Respir Crit Care Med 2007;28:121-7.

• Wijnen PAHM, op den Buijsch RAM, Drent M, Kuipers PMJC, Neef C, Bast A, Bekers O, Koek GH. Review article: the prevalence and clinical relevance of cytochrome P450 polymorphisms. Aliment Pharmacol Ther 2007; 26(Suppl 2):211–219

• Willems DC, Joore MA, Hendriks JJ, van Duurling RA, Wouters EF, Severens JL. Process evaluation of a nurse-led telemonitoring programme for patients with asthma. J Telemed Telecare 2007;13:310-7.

• Wouters EF. COPD: a chronic and overlooked pulmonary disease. [editorial] Lancet 2007;370:715-6.

• Wouters EFM. Decision Making in Chronic Hypercapnic Respiratory Failure. A Real Challenge! [editorial] Chest 2007;131;1622-1624

• Yanbaeva DG, Dentener MA, Creutzberg EC, Wesseling G, Wouters EFM. Systemic Effects of Smoking. Chest 2007;131:1557-1566.

• Zhu G, Warren L, Aponte J, Gulsvik A, Bakke P, Anderson WH, Lomas DA, Silverman EK, Pillai SG; International COPD Genetics Network (ICGN) Investigators including Wouters EFM. The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. Am J Respir Crit Care Med 2007;176:167-73

2006

• Anker SD, John M, Pedersen PU, Raguso C, Cicoira M, Dardai E, Laviano A, Ponikowski P, Schols AM; DGEM: H.F. Becker, M. Bohm, F.M. Brunkhorst, C. Vogelmeier. ESPEN Guidelines on Enteral Nutrition: Cardiology and Pulmonology. Clin Nutr 2006;25:311–318.

• Baughman RP, Drent M, Kavuru M, Judson MA, Costabel U, du Bois R, Albera C, Brutsche M, Davis G, Donohue JF, Muller-Quernheim J, Schlenker-Herceg R, Flavin S, Lo KH, Oemar B, Barnathan ES. Infliximab Therapy in Patients with Chronic Sarcoidosis and Pulmonary Involvement. Am J Respir Crit Care Med 2006;174:795–802.

• Belle A van, Büller HR, Huisman MV, Huisman PM, Kaasjager K, Kamphuisen PW, Kramer MH, Kruip MJ, Kwakkel-van Erp JM, Leebeek FW, Nijkeuter M, Prins MH, Sohne M, Tick LW; Christopher Study Investigators. Effectiveness of Managing Suspected Pulmonary Embolism Using an Algorithm Combining Clinical Probability, D-Dimer Testing, and Computed Tomography. JAMA 2006;295:172-179.
• Broekhuizen R, Wouters EF, Creutzberg EC, Schols AM. Elevated CRP levels mark metabolic and functional impairment in advanced COPD. Thorax 2006;61:17-22

• Darquennes K, De Jonghe P, Daems D, De Backer W, Verbraecken J. Intermittent positive airway pressure by nasal mask as a treatment for respiratory insufficiency in a patient with Charcot-Marie-Tooth disease. Acta Clin Belg 2006; 61-4.

• Dentener MA, Louis R, Cloots RH, Henket M, Wouters EF. Differences in local versus systemic TNFalpha production in COPD: inhibitory effect of hyaluronan on LPS induced blood cell TNFalpha release. Thorax 2006;61:478-84.

• Geraets L, Moonen HJ, Wouters EF, Bast A, Hageman GJ. Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations. Biochem Pharmacol 2006;72:902-910.

• Gosker HR, Schrauwen P, Broekhuizen R, Hesselink MK, Moonen-Kornips E, Ward KA, Franssen FF, Wouters EF, Schols AM. Exercise training restores uncoupling protein-3 content in limb muscles of patients with chronic obstructive pulmonary disease. Am J Physiol - Endocrinol Metab 2006;290:E976-E981.

• Hoeks J, Hesselink MK, Sluiter W, Schaart G, Willems J, Morrisson A, Clapham JC, Saris WH, Schrauwen P. The effect of high-fat feeding on intramuscular lipid and lipid peroxidation levels in UCP3-ablated mice. FEBS Lett 2006;580:1371-5

• Hogervorst JG, de Kok TM, Briede JJ, Wesseling G, Kleinjans JC, van Schayck CP. Relationship between Radical Generation by Urban Ambient Particulate Matter and Pulmonary Function of School Children. J Toxicol Environ Health A. 2006;69:245-62.

• Hoitsma E, Faber CG, van Santen-Hoeufft M, De Vries J, Reulen JP, Drent M. Improvement of small fiber neuropathy in a sarcoidosis patient after treatment with infliximab. Sarcoidosis Vasc Diffuse Lung Dis 2006;23:73-7.

• Huijnen B, van der Horst F, van Amelsvoort L, Wesseling G, Lansbergen M, Aarts P, Nicolson N, Knottnerus A. Dyspnea in elderly family practice patients. Occurrence, severity, quality of life and mortality over an 8-year period. Fam Pract 2006;23:34–39

• Kuiper S, Muris JW, Dompeling E, van Schayck CP, Schonberger HJ, Wesseling G, Knottnerus JA. Association between first-degree familial predisposition of asthma and atopy (total IgE) in newborns. Clin Exp Allergy 2006;36:594-601.

• Langen RCJ, Schols AMWJ, Kelders MCJM, van der Velden JLJ, Wouters EFM, Janssen-Heininger YMW. Muscle Wasting and Impaired Muscle Regeneration in a Murine Model of Chronic Pulmonary Inflammation. Am J Respir Cell Mol Biol 2006;35:689–696.

• Linssen CF, Jacobs JA, Beckers P, Templeton KE, Bakkers J, Kuijper EJ, Melchers WJ, Drent M, Vink C. Inter-laboratory comparison of three different real-time PCR assays for the detection of Pneumocystis jiroveci in bronchoalveolar lavage fluid samples. J Med Microbiol 2006; 55:1229-35.

• Michielsen HJ, Drent M, Peros-Golubicic T,De Vries J. Fatigue Is Associated With Quality of Life in Sarcoidosis Patients. Chest 2006;130:989–994
• Nici L, Donner C, Wouters E, Zuwallack R, Ambrosino N, Bourbeau J, Carone M, Celli B, Engelen M, Fahy B, Garvey C, Goldstein R, Gosselink R, Lareau S, Macintyre N, Maltais F, Morgan M, O'donnell D, Prefault C, Reardon J, Rochester C, Schols A, Singh S, Troosters T. ATS/ERS statement on pulmonary rehabilitation. Am J Respir Crit Care Med. 2006;173:1390-413.

• Pantano C, Reynaert NL, Vliet AV, Janssen-Heininger YM. Redox-Sensitive Kinases of the Nuclear Factor-kappaB Signaling Pathway. Antioxid Redox Signal 2006;8:1791-806.

• Reynaert NL, Ckless K, Guala AS, Wouters EFM, van der Vliet A, Janssen-Heininger YMW. In situ detection of S-glutathionylated proteins following glutaredoxin-1 catalyzed cysteine derivatization. Biochim Biophys Acta (BBA) 2006; 1760:380-387

• Reynaert NL, van der Vliet A, Guala AS, McGovern T, Hristova M, Pantano C, Heintz NH, Heim J, Ho YS, Matthews DE, Wouters EF, Janssen-Heininger YM. Dynamic redox control of NF-{kappa}B through glutaredoxin-regulated S-glutathionylation of inhibitory {kappa}B kinase {beta}. Proc Natl Acad Sci USA 2006;103:13086-13091.

• Rosias PP, Robroeks CM, Niemarkt HJ, Kester AD, Vernooy JH, Suykerbuyk J, Teunissen J, Heynens J, Hendriks HJ, Jobsis Q, Dompeling E. Breath condenser coatings affect measurement of biomarkers in exhaled breath condensate. Eur Respir J 2006;28:1036-41

• Rutten EP, Engelen MP, Wouters EF, Deutz NE, Schols AM. Effect of glutamate ingestion on whole-body glutamate turnover in healthy elderly and patients with chronic obstructive pulmonary disease. Nutrition 2006

• Rutten EP, Engelen MP, Wouters EF, Schols AM, Deutz NE. Metabolic effects of glutamine and glutamate ingestion in healthy subjects and in persons with chronic obstructive pulmonary disease. Am J Clin Nutr 2006;83:115-23.

• Rutten EP, Franssen FM, Engelen MP, Wouters EF, Deutz NE, Schols AM. Greater whole-body myofibrillar protein breakdown in cachectic patients with chronic obstructive pulmonary disease. Am J Clin Nutr 2006;83:829-34.

• Ruysscher D De, Bremer RH, Koppe F, Wanders S, van Haren E, Hochstenbag M, Geeraedts W, Pitz C, Simons J, Ten Velde G, Dohmen J, Snoep G, Boersma L, Verschueren T, van Baardwijk A, Dehing C, Pijls M, Minken A, Lambin P. Omission of elective node irradiation on basis of CT-scans in patients with limited disease small cell lung cancer: A phase II trial. Radiother Oncol 2006;80:307-12.

• Ruysscher D De, Pijls-Johannesma M, Bentzen SM, Minken A, Wanders R, Lutgens L, Hochstenbag M, Boersma L, Wouters B, Lammering G, Vansteenkiste J, Lambin P. Time between the first day of chemotherapy and the last day of chest radiation is the most important predictor of survival in limited-disease small-cell lung cancer. J Clin Oncol 2006;24:1057-63.

• Satapathy AK, Sartono E, Sahoo PK, Dentener MA, Michael E, Yazdanbakhsh M, Ravindran B. Human bancroftian filariasis: immunological markers of morbidity and infection. Microbes Infect 2006;8:2414-2423

• Schilstra A, Rottoli P, Jacobs JA, van Suylen RJ,Galluzzi P, Drent M. Case studies to explore the pitfalls in the diagnosis of sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2006;23:135-140

• Seute T, Leffers P, Wilmink JT, ten Velde GP, Twijnstra A. Response of asymptomatic brain metastases from small-cell lung cancer to systemic first-line chemotherapy. J Clin Oncol 2006;24:2079-83.

• Shivalkar B, Van de Heyning C, Kerremans M, Rinkevich D, Verbraecken J, De Backer W, Vrints C. Obstructive sleep apnea syndrome: more insights on structural and functional cardiac alterations, and the effects of treatment with continuous positive airway pressure. J Am Coll Cardiol. 2006; 47:1433-9

• Spruit MA, Janssen PP, Willemsen SC, Hochstenbag MM, Wouters EF. Exercise capacity before and after an 8-week multidisciplinary inpatient rehabilitation program in lung cancer patients: A pilot study. Lung Cancer 2006;52:257-260.

• Steuten L, Vrijhoef B, Van Merode F, Wesseling GJ, Spreeuwenberg C. Evaluation of a regional disease management programme for patients with asthma or chronic obstructive pulmonary disease. Int J Qual Health Care 2006;18:429-436.

• Uden CJ van , Ament AJ, Voss GB, Wesseling G, Winkens RA, van Schayck OC, Crebolder HF. Out-of-hours primary care. Implications of organisation on costs. BMC Fam Pract 2006;7:29

• Uszko-Lencer NH, Bothmer F, van Pol PE, Schols AM. Measuring body composition in chronic heart failure: A comparison of methods. Eur J Heart Fail 2006; 8: 208-214.

• Velden JL van der, Langen RC, Kelders MC, Wouters EF, Janssen-Heininger YM, Schols AM. Inhibition of Glycogen Synthase Kinase 3ß activity is sufficient to stimulate myogenic differentiation. Am J Physiol Cell Physiol 2006;290:C453 - C462

• Verbraecken J, Heyning P van de, De Backer Wilfried, Van Gaal Luc. Body surface area in normal-weight, overweight, and obese adults. A comparison study. Metabolism 2006;55:515–524

• Vermeeren MA, Creutzberg EC, Schols AM, Postma DS, Pieters WR, Roldaan AC, Wouters EF; on behalf of the COSMIC Study Group. Prevalence of nutritional depletion in a large out-patient population of patients with COPD. Respir Med 2006; 100:1349-1355

• Vries J de, Drent M. Quality of life and health status in interstitial lung diseases. Curr Opin Pulm Med 2006; 12:354-358.

• Willems DC, Joore MA, Hendriks JJ, Wouters EF, Severens JL. Cost-effectiveness of self-management in asthma: A systematic review of peak flow monitoring interventions. Int J Technol Assess Health Care 2006;22:436-42.

• Wouters EF. Muscle wasting in chronic obstructive pulmonary disease: to bother and to measure! [editorial] Am J Respir Crit Care Med 2006;173:4-5.

• Wouters EF. The systemic face of airway diseases: the role of C-reactive protein. [editorial] Eur Respir J 2006;27:877-9.

2005

• Broekhuizen R, Creutzberg EC, Weling-Scheepers CA, Wouters EF, Schols AM. Optimizing oral nutritional drink supplementation in patients with chronic obstructive pulmonary disease. Br J Nutr 2005;93:965-71.

• Broekhuizen R, Grimble RF, Howell WM, Shale DJ, Creutzberg EC, Wouters EF, Schols AM. Pulmonary cachexia, systemic inflammatory profile, and the interleukin 1β-511 single nucleotide polymorphism. Am J Clin Nutr 2005;82:1059–64.

• Broekhuizen R, Vernooy JHJ, Schols AMWJ, Dentener MA, Wouters EFM. Leptin as local inflammatory marker in COPD. Respir Med 2005; 99:70-74

• Broekhuizen R, Wouters EFM, Creutzberg EC, Weling-Scheepers CAPM, Schols AMWJ. Polyunsaturated fatty acids improve exercise capacity in chronic obstructive pulmonary disease. Thorax 2005;60:376–382.

• Celli BR, Calverley PM, Rennard SI, Wouters EF, Agusti A, Anthonisen N, Macnee W, Jones P, Pride N, Rodriguez-Roisin R, Rossi A, Wanner A. Proposal for a multidimensional staging system for chronic obstructive pulmonary disease. Respir Med 2005;99:1546-1554.

• Chavannes NH, Huibers MJ, Schermer TR, Hendriks A, van Weel C, Wouters EF, van Schayck CP. Associations of depressive symptoms with gender, body mass index and dyspnea in primary care COPD patients. Fam Pract 2005; 22:604-607.

• Dentener MA, Vernooy JHJ, Hendriks S, Wouters EFM. Enhanced levels of hyaluronan in lungs of patients with COPD: relationship with lung function and local inflammation. Thorax 2005;60:114–119.

• Engelen MP, Rutten EP, De Castro CL, Wouters EF, Schols AM, Deutz NE. Altered interorgan response to feeding in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 2005;82:366-72.

• Franssen FM, Broekhuizen R, Janssen PP, Wouters EF, Schols AM. Limb Muscle Dysfunction in COPD: Effects of Muscle Wasting and Exercise Training. Med Sci Sports Exerc 2005;37:2-9.

• Gosker HR, Bast A, Haenen GRMM, Fischer MAJG , van der Vusse GJ, Wouters EFM, AMWJ Schols. Altered antioxidant status in peripheral skeletal muscle of patients with COPD. Respir Med 2005; 99:118-125

• Haegens A, van der Vliet A, Butnor KJ, Heintz N, Taatjes D, Hemenway D, Vacek P, Freeman BA, Hazen SL, Brennan ML, Mossman BT. Asbestos-induced lung inflammation and epithelial cell proliferation are altered in myeloperoxidase-null mice. Cancer Res 2005;65:9670-7.

• Ham EC van den, Kooman JP, Schols AM, Nieman FH, Does JD, Franssen FM, Akkermans MA, Janssen PP, van Hooff JP. Similarities in skeletal muscle strength and exercise capacity between renal transplant and hemodialysis patients. Am J Transplant 2005;5:1957-65.

• Hoitsma E, Faber CG, van Kroonenburgh MJPG, Gorgels APM, Halders SGEA, Heidendal GAK, Kessels AGH, Reulen JPH, Drent M. Association of small fiber neuropathy with cardiac sympathetic dysfunction in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2005;22:43-50

• Hoogendoorn M, Rutten-van Molken MP, Hoogenveen RT, van Genugten ML, Buist AS, Wouters EF, Feenstra TL. A dynamic population model of disease progression in COPD. Eur Respir J 2005;26:223-33.

• Jacobs JA, Stobberingh EE, Cornelissen EIM, Drent M.Detection of Streptococcus pneumoniae Antigen in Bronchoalveolar Lavage Fluid Samples by a Rapid Immunochromatographic Membrane Assay. J Clin Microbiol 2005;43:4037–4040.

• Janssen-Heininger Y, Ckless K, Reynaert N, van der Vliet A. SOD Inactivation in Asthma. Bad News or NO News? Am J Pathol 2005;166:649-652

• Luijendijk SCM, Zegers IHA, van der Grinten CPM. A discussion regarding the contribution of intrapulmonary gas mixing to O2 isotope fractionation by respiration using experimental data for 36Ar and 40Ar. Respir Physiolo Neurobiol 2005;147:73-80

• Malm J, Nordahl EA, Bjartell A, Sorensen OE, Frohm B, Dentener MA, Egesten A. Lipopolysaccharide-binding protein is produced in the epididymis and associated with spermatozoa and prostasomes. J Reprod Immunol 2005;66:33-43.

• Mercken EM, Hageman GJ, Schols AM, Akkermans MA, Bast A, Wouters EF. Rehabilitation Decreases Exercise-induced Oxidative Stress in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2005; 172:994-1001.

• Michielsen HJ, De Vries J, Drent M, Peros-Golubicic T. Psychometric qualities of the Fatigue Assessment Scale in Croatian sarcoidosis patients. Sarcoidosis Vasc Diffuse Lung Dis 2005;22:133-8.

• Moonen HJ, Geraets L, Vaarhorst A, Bast A, Wouters EF, Hageman GJ. Theophylline prevents NAD(+) depletion via PARP-1 inhibition in human pulmonary epithelial cells. Biochem Biophys Res Commun 2005;338:1805-10

• Reynaert NL, Ckless K, Wouters EFM, van der Vliet A, Janssen-Heininger Y. Nitric oxide and redox signaling in allergic airway inflammation, Antioxid Redox Signal 2005; 7: 129-143.

• Ruysscher D De, Wanders S, Minken A, Lumens A, Schiffelers J, Stultiens C, Halders S, Boersma L, Baardwijk A, Verschueren T, Hochstenbag M, Snoep G, Wouters B, Nijsten S, Bentzen SM, Kroonenburgh M, Ollers M, Lambin P. Effects of radiotherapy planning with a dedicated combined PET-CT-simulator of patients with non-small cell lung cancer on dose limiting normal tissues and radiation dose-escalation: A planning study. Radiother Oncol 2005;77:5-10.

• Ruysscher D De, Wanders S, van Haren E, Hochstenbag M, Geeraedts W, Utama I, Simons J, Dohmen J, Rhami A, Buell U, Thimister P, Snoep G, Boersma L, Verschueren T, van Baardwijk A, Minken A, Bentzen SM, Lambin P. Selective mediastinal node irradiation based on FDG-PET scan data in patients with non-small-cell lung cancer: A prospective clinical study. Int J Radiat Oncol Biol Phys 2005;62:988-94.

• Rutten EP, Engelen MP, Castro CL, Wouters EF, Schols AM, Deutz NE. Decreased Whole-Body and Splanchnic Glutamate Metabolism in Healthy Elderly Men and Patients with Chronic Obstructive Pulmonary Disease in the Postabsorptive State and in Response to Feeding. J Nutr 2005;135:2166-2170.

• Rutten EP, Engelen MP, Schols AM, Deutz NE. Skeletal muscle glutamate metabolism in health and disease: state of the art. Curr Opin Clin Nutr Metab Care 2005;8:41-51.

• Schilstra A, van Tuijl JH, van Suylen RJ, Faber CG, ten Velde GP. Unclassified rhabdomyosarcoma in a patient with anti-Hu syndrome. Acta Clin Belg 2005;60:248-51
• Schols AM, Broekhuizen R, Weling-Scheepers CA, Wouters EF. Body composition and mortality in chronic obstructive pulmonary disease. Am J Clin Nutr 2005;82:53-9.

• Seute T, Leffers P, Ten Velde GP, Twijnstra A. Leptomeningeal metastases from small cell lung carcinoma. Cancer 2005; 104; 1700-1705.

• Uden CJ van, Nieman FH, Voss GB, Wesseling G, Winkens RA, Crebolder HF. General practitioners' satisfaction with and attitudes to out-of-hours services. BMC Health Serv Res 2005;5:27

• Uden CJ van, Winkens RA, Wesseling G, Fiolet HF, van Schayck OC, Crebolder HF. The Impact of a Primary Care Physician Cooperative on the Caseload of an Emergency Department: The Maastricht Integrated Out-of-Hours Service. J Gen Intern Med 2005;20:559-64.

• Vernooy JH, Reynaert N, Wolfs TG, Cloots RH, Haegens A, Vries B, Dentener MA, Buurman WA, Wouters EM. Rapid pulmonary expression of acute-phase reactants after local lipopolysaccharide exposure in mice is followed by an interleukin-6 mediated systemic acute-phase response. Exp Lung Res 2005; 31:855-71.

• Voorter CEM, Drent M, van den Berg-Loonen EM. Severe pulmonary sarcoidosis is strongly associated with the haplotype HLA-DQB1*0602–DRB1*150101. Hum Immunol 2005; 66:826–835.

• Voorter CE, Drent M, Hoitsma E, Faber KG, van den Berg-Loonen EM. Association of HLA DQB1 0602 in sarcoidosis patients with small fiber neuropathy. Sarcoidosis Vasc Diffuse Lung Dis 2005;22:129-32.

• Wagena EJ, van Amelsvoort LG, Kant I, Wouters EF. Chronic bronchitis, cigarette smoking, and the subsequent onset of depression and anxiety: results from a prospective population-based cohort study. Psychosom Med 2005;67:656-60.

• Wagena EJ, Arrindell WA, Wouters EF, van Schayck CP. Are patients with COPD psychologically distressed? Eur Respir J 2005;26:242-8.

• Wagena EJ, Knipschild PG, Huibers MJ, Wouters EF, van Schayck CP. Efficacy of bupropion and nortriptyline for smoking cessation among people at risk for or with chronic obstructive pulmonary disease. Arch Intern Med 2005;165:2286-92.

• Wel A van Der, Nijsten S, Hochstenbag M, Lamers R, Boersma L, Wanders R, Lutgens L, Zimny M, Bentzen SM, Wouters B, Lambin P, De Ruysscher D. Increased therapeutic ratio by (18)FDG-PET CT planning in patients with clinical CT stage N2-N3M0 non-small-cell lung cancer: A modeling study. Int J Radiat Oncol Biol Phys 2005;61:649-55.

• Wouters EF, Postma DS, Fokkens B, Hop WC, Prins J, Kuipers AF, Pasma HR, Hensing CA, Creutzberg EC. Withdrawal of fluticasone propionate from combined salmeterol/fluticasone treatment in patients with COPD causes immediate and sustained disease deterioration: a randomised controlled trial. Thorax 2005;60:480-7.

Miscellaneous:

• ATS/ERS Task force, including CP van der Grinten. Nr 1. General considerations for lung function testing. Eur Respir J 2005;26:153-161.

• ATS/ERS Task force, including CP van der Grinten. Nr 2. Standardisation of spirometry. Eur Respir J 2005;26:319-38.

• ATS/ERS Task force, including CP van der Grinten. Nr 3. Standardisation of the measurement of lung volumes. Eur Respir J 2005;26:511-22.

• ATS/ERS Task force, including CP van der Grinten. Nr 4. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J 2005;26:720-735.

• ATS/ERS Task force, including CP van der Grinten. Nr 5. Interpretative strategies for lung function tests. Eur Respir J 2005;26:948-968.

• ATS Statement, including A. Schols. Statement on Home Care for Patients with Respiratory Disorders. Am J Respir Crit Care Med 2005; 171: 1443–1464.
• Including the Ifigenia study group including M. Drent. High-dose acetylcysteine in idiopathic pulmonary fibrosis. N Engl J Med 2005;353:2229-42.

2004

• Blaauw I de, Schols AMWJ, Koerts-deLang E, Wouters EFM, Deutz NEP. De novo glutamine synthesis induced by corticosteroids in vivo in rats is secondary to weight loss. Clin Nutr 2004; 23: 1035-1042.

• Brug J, Schols A, Mesters I. Dietary change, nutrition education and chronic obstructive pulmonary disease. Patient Educ Couns 2004;52:249-57.

• Ckless K, Reynaert NL, Taatjes DJ, Lounsbury KM, van der Vliet A, Janssen-Heininger Y. In situ detection and visualization of S-nitrosylated proteins following chemical derivatization: identification of Ran GTPase as a target for S-nitrosylation. Nitric Oxide 2004;11:216-27.

• Coorts S.L.M., Hasselbaink D.M., Koonen D.P., Willems J., Coumans W.A. et al. Enhanced sarcolemmal FAT/CD36 content and triacylglycerol storage in cardiac myocytes from obese zucker rats. Diabetes 2004;53:1655-1663.

• Creutzberg EC. Factors associated with prognosis in COPD: influence of body composition and systemic corticosteroid use on morbidity and mortality. Chron Respir Dis 2004;1:79-81.

• Dam KG van, Van Der Grinten CP, Luijendijk SC. The influence of training on oxygen isotope fractionation in healthy subjects. Respir Physiol Neurobiol 2004;141:73-84.

• Dompeling E, Jobsis Q, Vandevijver NM, Wesseling G, Hendriks H. Chronic bronchiolitis in a 5-yr-old child after exposure to sulphur mustard gas. Eur Respir J 2004;23:343-6.

• Engelen MP, Orozco-Levi M, Deutz NE, Barreiro E, Hernandez N, Wouters EF, Gea J, Schols AM. Glutathione and glutamate levels in the diaphragm of patients with chronic obstructive pulmonary disease. Eur Respir J 2004;23:545-51.

• Franssen FM, Broekhuizen R, Janssen PP, Wouters EF, Schols AM. Effects of Whole-Body Exercise Training on Body Composition and Functional Capacity in Normal-Weight Patients With COPD. Chest 2004;125:2021-8.

• Hoitsma E, Faber CG, Drent M, Sharma OP. Neurosarcoidosis: a clinical dilemma. Lancet Neurol 2004; 3: 397–407.

• Hoitsma E, Reulen JPH, de Baets M, Drent M, Spaans F, Faber CG. Small fiber neuropathy: a common and important clinical disorder. J Neurol Sciences 2004; 227: 119-30.

• Langen RC, Van Der Velden JL, Schols AM, Kelders MC, Wouters EF, Janssen-Heininger YM. Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization. FASEB J 2004; 18:227-37.

• Luiken J.J.F.P., Coort S.L.M, Willems J, Coumans W.A., Bonen A, Glatz J.F. Reactive type II pneumocytes in bronchoalveolar lavage fluid. Acta Cytologica 2004:48; 497-504.

• Palmen M., Daemen M.j.Q.p., Windt de L.J., Willems J., et al. Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor protein kinase C and tyrosine kinase-dependent mechanism. J Am Coll Cardiol 2004;44:1113-1123.

• Poletti V, Costabel U, Casoni GL, Bigliazzi C, Drent M, Olivieri D. Rare Infiltrative Lung Diseases: A Challenge for Clinicians. Respiration 2004;71:431–443

• Reynaert NL, Ckless K, Korn SH, Vos N, Guala AS, Wouters EF,Van Der Vliet A, Janssen-Heininger YM. Nitric oxide represses inhibitory {kappa}B kinase through S-nitrosylation. Proc Natl Acad Sci USA 2004; 101: 8945-8950.

• Rijke JM de, Schouten LJ, Velde GP, Wanders SL, Bollen EC, Lalisang RI, Dijck JA, Kramer GW, Brandt PA. Influence of age, comorbidity and performance status on the choice of treatment for patients with non-small cell lung cancer; results of a population-based study. Lung Cancer 2004;46:233-45.

• Rosias PP, Dompeling E, Dentener MA, Pennings HJ, Hendriks HJ, Van Iersel MP, Jobsis Q. Childhood asthma: Exhaled markers of airway inflammation, asthma control score, and lung function tests. Pediatr Pulmonol 2004;38:107-14.

• Schooten FJ Van, Boots AW, Knaapen AM, Godschalk RW, Maas LM, Borm PJ, Drent M, Jacobs JA. Myeloperoxidase (MPO) -463G->A Reduces MPO Activity and DNA Adduct Levels in Bronchoalveolar Lavages of Smokers. Cancer Epidemiol Biomarkers Prev 2004;13:828-33.

• Seute T, Leffers P, Ten Velde GP, Twijnstra A. Neurologic disorders in 432 consecutive patients with small cell lung carcinoma. Cancer 2004;100:801-6.

• Vanderveken OM, Boudewyns AN, Braem MJ, Okkerse W, Verbraecken JA, Willemen M, Wuyts FL, De Backer WA, Van de Heyning PH. Pilot study of a novel mandibular advancement device for the control of snoring. Acta Otolaryngol 2004; 124:628-33.

• Verbraecken J, Hoitsma E, van der Grinten CPM, Cobben NAM, Wouters EFM, Drent M. Sleep disturbances associated with periodic leg movements in chronic sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2004;21:137-146

• Vermeeren MAP, Wouters EFM, Geraerts-Keeris AJW, Schols AMWJ. Nutritional support in patients with chronic obstructive pulmonary disease during hospitalization for an acute exacerbation; a randomized controlled feasibility trial. Clin Nutr 2004; 23: 1184-1192

• Vernooy JHJ, Lindeman JHN, Jacobs JA, Hanemaaijer R, Wouters EFM. Increased Activity of Matrix Metalloproteinase-8 and Matrix Metalloproteinase-9 in Induced Sputum From Patients With COPD. Chest 2004; 126:1802-1810

• De Vries J, Michielsen H, Van Heck GL, Drent M. Measuring fatigue in sarcoidosis: The Fatigue Assessment Scale (FAS). Br J Health Psychol 2004;9:279-91.

• De Vries J, Rothkrantz-Kos S, van Dieijen-Visser MP, Drent M. The relationship between fatigue and clinical parameters in pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2004;21:127-136.

• Wagena EJ, Kant I, Huibers MJ, van Amelsvoort LG, Swaen GM, Wouters EF, van Schayck CP. Psychological distress and depressed mood in employees with asthma, chronic bronchitis or emphysema: a population-based observational study on prevalence and the relationship with smoking cigarettes. Eur J Epidemiol 2004;19:147-53.

• Wagena EJ, Kant I, Van Amelsvoort LG, Wouters EF, Van Schayck CP, Swaen GM. Risk of Depression and Anxiety in Employees With Chronic Bronchitis: The Modifying Effect of Cigarette Smoking. Psychosom Med 2004;66:729-734.

• Wouters EF. Management of severe COPD. Lancet 2004;364:883-95.

Miscellaneous:

• ATS/ERS Task Force, including Wouters EFM. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004; 23: 932–946.

• ESPEN Working group, including Schols AM. Bioelectrical impedance analysis - part I: review of principles and methods. Clin Nutr 2004; 23: 1226-1243.

• ESPEN Working group, including Schols AM. Bioelectrical impedance analysis—part II: utilization in clinical practice. Clin Nutr 2004:23: 1430-1453.

Not full text:

• Linssen KC, Jacobs JA, Poletti VE, van Mook W, Cornelissen EI, Drent M. Reactive type II pneumocytes in bronchoalveolar lavage fluid. Acta Cytol 2004; 48:497-504.

• De Vries J, Drent M. Relationship between perceived stress and sarcoidosis in a Dutch patient population. Sarcoidosis Vasc Diffuse Lung Dis 2004;21:57-63.

2003

• Creutzberg EC, Casaburi R. Endocrinological disturbances in chronic obstructive pulmonary disease. Eur Respir J Suppl. 2003;46:76s-80s.

• Creutzberg EC, Wouters EF, Mostert R, Pluymers RJ, Schols AM. A Role for Anabolic Steroids in the Rehabilitation of Patients With COPD?: A Double-Blind, Placebo-Controlled, Randomized Trial. Chest 2003;124:1733-42.

• Creutzberg EC, Wouters EFM, Mostert R, Weling-Scheepers CAPM, Schols AMWJ. Efficacy of nutritional supplementation therapy in depleted patients with Chronic Obstructive Pulmonary Disease. Nutrition 2003;19:120-127.

• Drent M. Sarcoidosis: benefits of a multidisciplinary approach. Eur J Int Med 2003;14:217-220.

• Drent M, Du Bois RM, Poletti V. Recent advances in the diagnosis and management of nonspecific interstitial pneumonia. Curr Opin Pulm Med 2003;9:411-7.

• Drent M, De Vries J, Lenters M, Lamers RJS, Rothkranz-Kos S, Wouters EFM, van Dieijen-Visser MP, Verschakelen JA. Sarcoidosis: assessment of disease severity using HRCT. Eur Radiol 2003;13:2462–2471.

• Drent M, Singh S, Gorgels AP, Hansell DM, Bekers O, Nicholson AG, Van Suylen RJ, Du Bois RM. Drug-induced Pneumonitis and Heart Failure Simultaneously Associated with Venlafaxine. Am J Respir Crit Care Med 2003; 167: 958-61.

• Engelen MP, Deutz NE, Mostert R, Wouters EF, Schols AM. Response of whole-body protein and urea turnover to exercise differs between patients with chronic obstructive pulmonary disease with and without emphysema. Am J Clin Nutr 2003; 77: 868-874.

• Engelen MP, Schols AM. Altered amino acid metabolism in chronic obstructive pulmonary disease: new therapeutic perspective? Curr Opin Clin Nutr Metab Care 2003; 6: 73-8.

• Goris AHC, Vermeeren MAP, Wouters EFM, Schols AMWJ, Westerterp KR. Energy balance in depleted ambulatory patients with chronic obstructive pulmonary disease: the effect of physical activity and oral nutritional supplementation. Brit J Nutr 2003; 89: 725-729.

• Gosker HR, Kubat B, Schaart G, van der Vusse GJ, Wouters EFM, Schols AMWJ. Myopathological features in skeletal muscle of patients with chronic obstructive pulmonary disease. Eur Respir J 2003;22:280-285.

• Gosker HR, Lencer NHMK, Franssen FME, van der Vusse GJ, Wouters EFM, Schols AMWJ. Striking similarities in systemic factors contributing to decreased exercise capacity in patients with severe chronic heart failure or COPD. Chest 2003; 123: 1416-1424.

• Gosker HR, Schrauwen P, Hesselink MK, Schaart G , van der Vusse GJ, Wouters EF, Schols AM. Uncoupling protein-3 content is decreased in peripheral skeletal muscle of patients with COPD. Eur Respir J 2003; 22: 88-93

• Groenewegen KH, Schols AM, Wouters EF. Mortality and mortality-related factors after hospitalization for acute exacerbation of COPD. Chest 2003; 124:459-67.

• Groenewegen KH, Wouters EF. Bacterial infections in patients requiring admission for an acute exacerbation of COPD; a 1-year prospective study. Respir Med 2003;97:770-7.

• Hageman GJ, Larik I, Pennings HJ, Haenen GR, Wouters EF, Bast A. Systemic poly(ADP-ribose) polymerase-1 activation, chronic inflammation, and oxidative stress in COPD patients. Free Radic Biol Med 2003;35:140-8.

• Hochstenbag MM, Twijnstra A, Hofman P, Wouters EF, ten Velde GP. MR-imaging of the brain of neurologic asymptomatic patients with large cell or adenocarcinoma of the lung. Does it influence prognosis and treatment? Lung Cancer 2003;42:189-93.

• Hoitsma E, Drent M, Verstraete E, Faber CG, Troost J, Spaans F, Reulen JP. Abnormal warm and cold sensation thresholds suggestive of small-fibre neuropathy in sarcoidosis. Clin Neurophysiol 2003;114:2326-33.

• Ind PW, Laitinen L, Laursen L, Wenzel S, Wouters E, Deamer L, Nystrom P. Early clinical investigation of Viozan (sibenadet HCl), a novel D2 dopamine receptor, beta2-adrenoceptor agonist for the treatment of chronic obstructive pulmonary disease symptoms. Respir Med 2003;97 Suppl A:S9-21.

• Jagoe RT, Engelen MP. Muscle wasting and changes in muscle protein metabolism in chronic obstructive pulmonary disease. Eur Respir J Suppl. 2003;46:52s-63s.

• Langen RCJ, Korn SH, Wouters EFM. ROS in the local and systemic pathogenesis of COPD. Free Radic Biol Med 2003;35:226-35.

• Langen R, Schols A, Kelders M, Wouters E, Janssen-Heininger Y. Enhanced myogenic differentiation by extracellular matrix is regulated at the early stages of myogenesis. In Vitro Cell Dev Biol Anim 2003;39:163-169.

• Mattson KV, Abratt RP, ten Velde G, Krofta K. Docetaxel as neoadjuvant therapy for radically treatable stage III non-small-cell lung cancer: a multinational randomised phase III study. Ann Oncol 2003;14:116-22.

• Michel O, LeVan TD, Stern D, Dentener M, Thorn J, Gnat D, Beijer ML, Cochaux P, Holt PG, Martinez FD, Rylander R. Systemic responsiveness to lipopolysaccharide and polymorphisms in the toll-like receptor 4 gene in human beings. J Allergy Clin Immunol 2003;112:923-9.

• Rothkrantz-Kos S, Bekers O, Gubbels A, Drent M, Schmitz MP, Van Dieijen-Visser MP. Evaluation of two new high-sensitivity methods for C-reactive protein. Ann Clin Biochem 2003;40:398-405.

• Rothkrantz-Kos S, Drent M, Rutgers A, Heeringa P, De Vries J, Dieijen-Visser MP van, Cohen Tervaert JW. Relationship between myeloperoxidase promotor polymorphism and disease severity in sarcoidosis. Eur J Internal Med 2003;14:296–301

• Rothkrantz-Kos S, van Dieijen-Visser MP, Mulder PGH, Drent M. Potential usefulness of inflammatory markers to monitor respiratory functional impairment in sarcoidosis. Clin Chem 2003;49:1510–1517.

• Schols AM. Nutritional and metabolic modulation in chronic obstructive pulmonary disease management. Eur Respir J Suppl. 2003;46:81s-86s.

• Schols A. Nutritional modulation as part of the integrated management of chronic obstructive pulmonary disease. Proc Nutr Soc 2003; 62:783-91.

• Van Uden CJ, Winkens RA, Wesseling GJ, Crebolder HF, Van Schayck CP. Use of out of hours services: a comparison between two organisations. Emerg Med J 2003; 20:184-187.

• Verbraecken J, Paelinck BP, Willemen M, Van de Heyning P, De Backer W. Aortic root diameter and nasal intermittent positive airway pressure treatment in Marfan's syndrome. Clin Genet 2003;63:131-134.

• Vrijhoef HJ, Diederiks JP, Wesseling GJ, Van Schayck CP, Spreeuwenberg C. Undiagnosed patients and patients at risk for COPD in primary health care: early detection with the support of non-physicians. J Clin Nurs 2003;12:366-73.

• Wagena EJ, Zeegers MP, van Schayck CP, Wouters EF. Benefits and risks of pharmacological smoking cessation therapies in chronic obstructive pulmonary disease. Drug Saf 2003;26:381-403.

• Walraven D, van der Grinten CP, Bogaard JM, van der Ent CK, Luijendijk SC. Modeling of the expiratory flow pattern of spontaneously breathing cats. Respir Physiolo Neurobiol 2003;134:23-32.

• Wouters EF. Eat well to get well. Thorax 2003;58:739-40.

• Wouters EF. Introduction: systemic effects in chronic obstructive pulmonary disease. Eur Respir J Suppl 2003;46:1s

• Wouters EF. The societal impact of COPD in North America and Europe: an economic analysis of the Confronting COPD survey. Respir Med 2003; 97 Suppl C:S3-14.

• Wouters EF. The burden of COPD in The netherlands: results from the Confronting COPD survey. Respir Med 2003;97 Suppl C:S51-9.

• Zimny M, Hochstenbag M, Lamers R, Reinartz P, Cremerius U, ten Velde G, Buell U. Mediastinal staging of lung cancer with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose positron emission tomography and a dual-head coincidence gamma camera. Eur Radiol 2003;13:740-7.

Miscellaneous:

• Ardizzoni A, Manegold C, Debruyne C, Gaafar R, Buchholz E, Smit EF, Lianes P, ten Velde G, Bosquee L, Legrand C, Neumaier C, King K; EORTC lung cancer group. European organization for research and treatment of cancer (EORTC) 08957 phase II study of topotecan in combination with cisplatin as second-line treatment of refractory and sensitive small cell lung cancer. Clin Cancer Res 2003;9:143-50.

Not full text:

• Hoitsma E, De Vries J, van Santen-Hoeufft M, Faber CG, Drent M. Impact of pain in a Dutch sarcoidosis patient population. Sarcoidosis Vasc Diffuse Lung Dis 2003;20:33-9.

• Linssen KF, Jacobs JA, Nieman FH, Cornelissen LE, Drent M. Use of poly-l-lysine-coated slides in clinical bronchoalveolar lavage fluid samples. Anal Quant Cytol Histol 2003;25:281-4.

2002

• Besaratinia A, Maas LM, Brouwer EM, Moonen EJ, De Kok TM, Wesseling GJ, Loft S, Kleinjans JC, Van Schooten FJ. A molecular dosimetry approach to assess human exposure to environmental tobacco smoke in pubs. Carcinogenesis 2002;23:1171-1176.

• Chavannes N, Vollenberg J, Schayck van O, Wouters E. Effects of physical activity in mild to moderate COPD: a systematic review. British Journal of General Practice 2002; 52: 574-578.

• Franssen FM, Wouters EF, Baarends EM, Akkermans MA, Schols AM. Arm mechanical efficiency and arm exercise capacity are relatively preserved in chronic obstructive pulmonary disease. Med Sci Sports Exerc 2002; 34: 1570-6.

• Franssen FME, Wouters EFM, Schols AMWJ. The contribution of starvation, deconditioning and ageing to the observed alterations in peripheral skeletal muscle in chronic organ diseases. Clin Nutr 2002; 21: 1-14.

• Godschalk RW, Feldker DE, Borm PJ, Wouters EF, Van Schooten FJ. Body Mass Index Modulates Aromatic DNA Adduct Levels and Their Persistence in Smokers. Cancer Epidemiol Biomarkers Prev 2002;11:790-793.

• Gosker HR, van Mameren H, van Dijk PJ, Engelen MP, van der Vusse GJ, Wouters EF, Schols AM. Skeletal muscle fibre-type shifting and metabolic profile in patients with chronic obstructive pulmonary disease. Eur respir J 2002; 19: 617-626.

• Gosker HR, Engelen MP, van Mameren H, van Dijk PJ, van der Vusse GJ, Wouters EF, Schols AM. Muscle fiber type IIX atrophy is involved in the loss of fat-free mass in chronic obstructive pulmonary disease. Am J Clin Nutr 2002: 76; 113-119.

• Gosker HR, Uszko-Lencer NHMK, Wouters EFM, van der Vusse GJ, Schols AMWJ. Muscular alterations in chronic obstructive pulmonary disease and chronic heart failure at rest and during exercise. Prog Respir Res 2002; 32: 18-29.

• Hoitsma E, Marziniak M, Faber CG, Reulen JPH, Sommer C, De Baets M, Drent M. Small fibre neuropathy in sarcoidosis. The Lancet 2002; 359: 2085-86.

• Kucukaycan M, Van Krugten M, Pennings HJ, Huizinga TW, Buurman WA, Dentener MA, Wouters EF. Tumor Necrosis Factor-alpha +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease. Respir Res 2002; 3: 29.

• Langen RC, Schols AM, Kelders MC, Van Der Velden JL, Wouters EF, Janssen-Heininger YM. Tumor necrosis factor-alpha inhibits myogenesis through redox-dependent and -independent pathways. Am J Physiol Cell Physiol 2002; 283: C714-21.

• Langendijk JA, Aaronson NK, de Jong JM, ten Velde GP, Muller MJ, Slotman BJ, Wouters EF. Quality of life after curative radiotherapy in Stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2002; 53: 847-53.

• Luijendijk SCM, van der Grinten CPM. The ratio of the alveolar ventilations of SF6 and He in patients with lung emphysema and in healthy subjects. Respir Physiol Neurobiol 2002; 130: 69-77.

• Luijendijk SC, van der Grinten CP. Collateral gas transport by diffusion across tissue in the healthy, human lung; effects on dead space. Respir Physiolo Neurobiol 2002; 133: 99-107.

• Poeze M, Ramsay G, Buurman WA, Greve JW, Dentener M, Takala J. Increased hepatosplanchnic inflammation precedes the development of organ dysfunction after elective high-risk surgery. Shock 2002;17:451-8.

• Pouw Kraan, TC Van Der, Kucukaycan M, Bakker AM, Baggen JM, Van Der Zee JS, Dentener MA, Wouters EF, Verweij CL. Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism. Genes Immun 2002;3:436-9.

• Rikers RJ, Schmidt HG, Boshuizen PA, Linssen GC, Wesseling GJ, FG Paas. The robustness of medical expertise: clinical case processing by medical experts and subexperts. Am J Psychology 2002; 115: 609-629.

• Sauerwein H, Schols A. Glucose metabolism in chronic lung disease. Clin Nutr 2002; 21: 367-371.

• Schols A. Pulmonary cachexia. Int J Cardiol 2002; 85: 101-110

• Schols AM, Westerterp KR. Hypoxia, nitrogen balance and body weight. Eur Respir J 2002; 20: 252-3.

• van Schayck CP, Loozen JM, Wagena E, Akkermans RP, Wesseling GJ. Detecting patients at a high risk of developing chronic obstructive pulmonary disease in general practice: cross sectional case finding study. BMJ. 2002: 324;1370.

• Verbraecken J, Willemen M, De Cock W, Van de Heyning P, De Backer W. Intermittent positive airway pressure by nasal mask as a treatment for respiratory insufficiency in a patient with syringomyelia. Respiration 2002; 69:169-174.

• Verbraecken J, Willemen M, Wittesaele W, Van de Heyning P, De Backer W. Short-term CPAP does not influence the increased CO2 drive in idiopathic central sleep apnea. Monaldi Arch Chest Dis 2002;57: 8-16.

• Vernooy JH, Dentener MA, van Suylen RJ, Buurman WA, Wouters EF. Long-term intratracheal lipopolysaccharide exposure in mice results in chronic lung inflammation and persistent pathology. Am J Respir Cell Mol Biol 2002;26: 152-9.

• Vernooy JH, Kucukaycan M, Jacobs JA, Chavannes NH, Buurman WA, Dentener MA, Wouters EF. Local and Systemic Inflammation in Patients with Chronic Obstructive Pulmonary Disease. Soluble Tumor Necrosis Factor Receptors Are Increased in Sputum. Am J Respir Crit Care Med 2002; 166: 1218-1224.

• Wouters EF. Chronic obstructive pulmonary disease * 5: Systemic effects of COPD. Thorax 2002; 57: 1067-70.

• Wouters EF, Creutzberg EC, Schols AM. Systemic Effects in COPD. Chest 2002;121:127S-30S.

Not full text:

• De Brauwer EI, Jacobs JA, Nieman F, Bruggeman CA, Drent M. Bronchoalveolar lavage fluid differential cell count. How many cells should be counted? Anal Quant Cytol Histol. 2002; 24: 337-41.

• Rothkrantz-Kos S, Drent M, Vuil H, Boer de M, Bast A, Wouters E, Roos D, Dieijen van-Visser M. Decreased redox state in red blood cells from patients with sarcoidosis. Sarcoidosis vasculitis and diffuse lung diseases 2002; 19: 114-120.

2001

• van Belle AF, Lamers RJ, ten Velde GP, Wouters EF. Diagnostic yield of computed tomography and densitometric measurements of the lung in thoracoscopically-defined idiopathic spontaneous pneumothorax. Respir Med 2001; 95 :292-6.

• Dentener MA, Creutzberg EC, Schols AM, Mantovani A, van't Veer C, Buurman WA, Wouters EF. Systemic anti-inflammatory mediators in COPD: increase in soluble interleukin 1 receptor II during treatment of exacerbations. Thorax 2001; 56: 721-6.

• van Dielen FM, van't Veer C, Schols AM, Soeters PB, Buurman WA, Greve JW. Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals. Int J Obes Relat Metab Disord 2001; 25: 1759-66.

• Drent M, Berg van den R, Haenen GRMM, Berg van den H, Wouters EFM, Bast A. NF-kB activation in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2001; 18:50-56.

• Drent M, Jacobs JA, Cobben NA, Costabel U, Wouters EF, Mulder PG. Computer program supporting the diagnostic accuracy of cellular BALF analysis: a new release. Respir Med 2001;95:781-6.

• Engelen MPKJ, Wouters EFM, Deutz NEP, Does JD, Schols AMWJ. Effects of Exercise on Amino Acid Metabolism in Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2001; 163: 859-864.

• Feenstra TL, van Genugten ML, Hoogenveen RT, Wouters EF, Rutten-Van Molken MP. The Impact of Aging and Smoking on the Future Burden of Chronic Obstructive Pulmonary Disease. A model analysis in the netherlands. Am J Respir Crit Care Med 2001; 164: 590-596. Data Supplement:

• Hendriks JJ, Kester AD, Donckerwolcke R, Forget PP, Wouters EF. Changes in pulmonary hyperinflation and bronchial hyperresponsiveness following treatment with lansoprazole in children with cystic fibrosis. Pediatr Pulmonol 2001; 31: 59-66.

• Jacobs J, Dieleman M, Cornelissen E, Groen E, Wagenaar S, Drent M. Bronchoalveolar Lavage Fluid Cytology in Patients with Pneumocystic carinii Pneumonia. Acta Cytol 2001; 45: 317-325.

• Korn SH, Wouters EF, Vos N, Janssen-Heininger YM. Cytokine-induced activation of nuclear factor-kappa B (NF-kB) is inhibited by hydrogen peroxide through oxidative inactivation of IkB kinase (IKK). J Biol Chem 2001; 276: 35693-700

• Langen RC, Schols AM, Kelders MC, Wouters EF, Janssen-Heininger YM. Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB. FASEB J 2001; 15: 1169-80.

• Langendijk JA, Aaronson NK, de Jong JM, ten Velde GP, Muller MJ, Lamers RJ, Slotman BJ, Wouters EF. Prospective Study on Quality of Life Before and After Radical Radiotherapy in Non-Small-Cell Lung Cancer. J Clin Oncol 2001; 19: 2123-2133.

• Langendijk H, de Jong J, Tjwa M, Muller M, ten Velde G, Aaronson N, Lamers R, Slotman B, Wouters M. External irradiation versus external irradiation plus endobronchial brachytherapy in inoperable non-small cell lung cancer: a prospective randomized study. Radiother Oncol 2001; 58: 257-268

• Michel O, Dentener M, Corazza F, Buurman W, Rylander R. Healthy subjects express differences in clinical responses to inhaled lipopolysaccharide that are related with inflammation and with atopy. J Allergy Clin Immunol 2001; 107: 797-804.

• Schiffelers SL, Blaak EE, Baarends EM, van Baak MA, Saris WH, Wouters EF, Schols AM. ß-Adrenoceptor-mediated thermogenesis and lipolysis in patients with chronic obstructive pulmonary disease. Am J Physiol Endocrinol Metab 2001; 280: E357–E364.

• Schols AMWJ, Wesseling G, Kester ADM, de Vries G, Mostert R, Slangen J, Wouters EFM. Dose dependent increased mortality risk in COPD patients treated with oral glucocorticoids. Eur Respir J 2001; 17: 337-342.

• Tjhie JHT, van Belle AF, Dessens-Kroon, van Soolingen D. Misidentification and Diagnostic Delay Caused by a False-Positive Amplified Mycobacterium tuberculosis Direct Test in an Immunocompetent Patient with a Mycobacterium celatum Infection. J Clin Microbiol 2001; 39:2311-2312.

• Verbraecken J, Declerck A, Van de Heyning P, De Backer W, Wouters EFM. Evaluation for sleep apnea in patients with Ehlers-Danlos syndrome and Marfan: a questionnaire study. Clinical Genetics 2001; 60: 360-365.

• Verbraecken J, Willemen M, De Cock W, Van De Heyning P, De Backer WA. Continuous positive airway pressure and lung inflation in sleep apnea patients. Respiration 2001;68:357-64.

• Verleden GM, Bois du RM, Bouros D, Drent M, Millar A, Muller-Quernheim J, Semenzato G, Johnson S, Sourvinos G, Olivieri D, Pietinalho A, Xaubet A. Genetic predisposition and pathogenetic mechanisms of interstital lung diseases of unknown origin. Eur Respir J 2001; 18:17s-29s.

• Vermeeren MAP, Wouters EFM, Nelissen LH, van Lier A, Hofman Z, Schols AM. Acute effects of different nutritional supplements on symptoms and functional capacity in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 2001; 73:295-301

• Vernooy JH, Dentener MA, van Suylen RJ, Buurman WA, Wouters EF. Intratracheal Instillation of Lipopolysaccharide in Mice Induces Apoptosis in Bronchial Epithelial Cells. No role for tumor necrosis factor-alpha and infiltrating neutrophils. Am J Respir Cell Mol Biol 2001 24: 569-76.

• Vries J De, Kessels BL, Drent M. Quality of life of idiopathic pulmonary fibrosis patients. Eur Respir J. 2001; 17:954-61.

2000

• Creutzberg EC, Schols AMWJ, Weling-Scheepers CAPM, Buurman WA, Wouters EFM. Characterization of Nonresponse to High Caloric Oral Nutritional Therapy in Depleted Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2000; 161: 745-752.

• Creutzberg EC, Wouters EFM, vanderHoven-Augustin IML, Dentener MA, Schols AMWJ. Disturbances in Leptin Metabolism Are Related to Energy Imbalance during Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2000; 162: 1239-1245

• Dentener MA, Vreugdenhil AC, Hoet PH, Vernooy JH, Nieman FH, Heumann D, Janssen YM, Buurman WA, Wouters EF. Production of the Acute-Phase Protein Lipopolysaccharide-Binding Protein by Respiratory Type II Epithelial Cells. Implications for local defense to bacterial endotoxins. Am J Respir Cell Mol Biol. 2000; 23: 146-153.

• Drent M, Bomans PH, Van Suylen RJ, Lamers RJ, Bast A, Wouters EF. Association of man-made mineral fibre exposure and sarcoidlike granulomas. Respir Med. 2000; 94: 815-20.

• Drent M, Verbraecken J, van Der Grinten C, Wouters E. Fatigue associated with obstructive sleep apnea in a patient with sarcoidosis. Respiration 2000; 67: 337-40.

• Drent M, Wessels S, Jacobs JA, Thijssen H. Association of Diffuse Alveolar Haemorrhage with Acquired Vitamin K Deficiency [letter]. Respiration 2000; 67: 697

• Engelen MPKJ, Deutz NEP, Wouters EFM, Schols AMWJ. Enhanced Levels of Whole-body Protein Turnover in Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2000;162: 1488-1492

• Engelen MPKJ, Schols AMWJ, Does JD, Gosker HR, Deutz NEP, Wouters EFM. Exercise-Induced Lactate Increase in Relation to Muscle Substrates in Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2000;162:1697-1704.

• Engelen MPKJ, Schols, AMWJ, Does JD, Deutz NEP, Wouters EFM. Altered Glutamate Metabolism Is Associated with Reduced Muscle Glutathione Levels in Patients with Emphysema. Am J Respir Crit Care Med 2000; 161: 98–103.

• Engelen MP, Schols AM, Does JD, Wouters EF. Skeletal muscle weakness is associated with wasting of extremity fat-free mass but not with airflow obstruction in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 2000;71:733-738.

• Engelen MP, Wouters EF, Deutz NE, Menheere PP, Schols AM. Factors contributing to alterations in skeletal muscle and plasma amino acid profiles in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 2000; 72:1480-7.

• Gatzemeier U, von Pawel J , Gottfried M, Velde GP, Mattson K, DeMarinis F, Harper P, Salvati F, Robinet G, Lucenti A, Bogaerts J, Gallant G. Phase III comparative study of high-dose cisplatin versus a combination of paclitaxel and cisplatin in patients with advanced non-small-cell lung cancer. J Clin Oncol 2000; 18: 3390-9.

• Gosker HR, Wouters EFM, van der Vusse GJ, Schols AMWJ. Skeletal muscle dysfunction in chronic obstructive pulmonary disease and chronic heart failure: underlying mechanisms and therapy perspectives. Am J Clin Nutr 2000; 71: 1033-1047.

• Hochstenbag MM, Twijnstra A, Wilmink JT, Wouters EF, ten Velde GP. Asymptomatic brain metastases (BM) in small cell lung cancer (SCLC): MR-imaging is useful at initial diagnosis. J Neurooncol 2000;48:243-8.

• Koerts-de Lang E, Schols AM, Rooyackers OE, Gayan-Ramirez G, Decramer M, Wouters EF. Different effects of corticosteroid-induced muscle wasting compared with undernutrition on rat diaphragm energy metabolism. Eur J Appl Physiol 2000; 82: 493-8

• Langendijk H, Aaronson NK, de Jong JM, ten Velde GP, Muller MJ, Wouters M. The prognostic impact of quality of life assessed with the EORTC QLQ-C30 in inoperable non-small cell lung carcinoma treated with radiotherapy. Radiother Oncol 2000; 55: 19-25.

• Langendijk JA, Aaronson NK, ten Velde GP, de Jong JM, Muller MJ, Wouters EF. Pretreatment quality of life of inoperable non-small cell lung cancer patients referred for primary radiotherapy. Acta Oncol 2000;39:949-58.

• Langendijk H, Thunnissen E, Arends JW, de Jong J, ten Velde G, Lamers R, Guinee D, Holden J, Wouters M. Cell proliferation and apoptosis in stage III inoperable non-small cell lung carcinoma treated by radiotherapy. Radiother Oncol 2000; 56:197-207.

• Langendijk JA, ten Velde GP, Aaronson NK, de Jong JM, Muller MJ, Wouters EF. Quality of life after palliative radiotherapy in non-small cell lung cancer: a prospective study. Int J Radiat Oncol Biol Phys 2000; 47: 149-155.

• Mostert R, Goris A, Weling-Scheepers C, Wouters EFM, Schols AMWJ. Tissue depletion and health related quality of life in patients with chronic obstructive pulmonary disease. Respir Med 2000; 9: 859-867.

• Nia AB, Maas LM, Van Breda SG, Curfs DM, Kleinjans JC, Wouters EF, Van Schooten FJ. Applicability of induced sputum for molecular dosimetry of exposure to inhalatory carcinogens: 32P-postlabeling of lipophilic DNA adducts in smokers and nonsmokers. Cancer Epidemiol Biomarkers Prev. 2000; 9: 367-72

• Pouw EM, Koerts-de Lang E, Gosker HR, Freling G, van der Vusse GJ, Wouters EF, Schols AM. Muscle metabolic status in patients with severe COPD with and without long-term prednisolone. Eur Respir J 2000; 16: 247-52.

• Pouw EM, Ten Velde GP, Croonen BH, Kester AD, Schols AM, Wouters EF. Early non-elective readmission for chronic obstructive pulmonary disease is associated with weight loss. Clin Nutr 2000; 19: 95-9.

• Schols AM. Nutrition in chronic obstructive pulmonary disease. Curr Opin Pulm Med 2000; 6: 110-115.

• Schols AM, Wouters EF. Nutritional abnormalities and supplementation in chronic obstructive pulmonary disease. Clin Chest Med 2000; 21: 753-762

• Verbraecken J, Willemen M, De Cocl W, Wittesaele W, Govaert K, Van de Heyning P, De Backer W. Influence of longterm CPAP therapy on CO2 drive in patients with obstructive sleep apnea. Respir Physiol 2000; 123: 121-130.

• Vries J De, Seebregts A, Drent M. Assessing health status and quality of life in idiopathic pulmonary fibrosis: which measure should be used? Respir Med 2000;94:273-8.

• Wouters EF. Nutrition and metabolism in COPD. Chest 2000; 117: 274S-80S

1999

• De Brauwer E, Jacobs J, Nieman F, Bruggeman C, Drent M. Test characteristics of acridine orange, Gram, and May-Grunwald-Giemsa stains for enumeration of intracellular organisms in bronchoalveolar lavage fluid. J Clin Microbiol 1999; 37: 427-429.

• Calverley P, Rennard S, Agusti A, Anthonisen N, Celli B, Cosio M, MacNee W, Rodriguez-Roisin R, Rossi A, Wanner A, Wouters E. Current and future management of acute exacerbations of chronic obstructive pulmonary disease. Eur Respir Rev 1999; 9:193-205.

• Cobben NAM, Drent M, Jacobs JA, Schmitz MPJ, Mulder PGH, Henderson RF, Wouters EFM, van Dieijen-Visser MP. Relationship between enzymatic markers of pulmonary cell damage and cellular profile:a study in bronchoalveolar lavage fluid. Exp Lung Res 1999; 25: 99-111

• Cobben NA, Drent M, De Vries J, Wouters EF, Van Dieijen-Visser MP, Henderson RF. Serum beta-glucuronidase activity in a population of ex-coalminers. Clin Biochem 1999;32:659-64.

• Cobben NA, Drent M, Van Dieijen-Visser MP, Mulder PG, Wouters EF, Henderson RF. Usefulness of monitoring beta-glucuronidase in pleural effusions. Clin Biochem 1999;32:653-8.

• Cobben NAM, Jacobs JA, van Dieijen-Visser MP, Mulder PGH, Wouters EFM, Drent M. Diagnostic value of BAL fluid cellular profile and enzymes in infectious pulmonary disorders Eur Respir J 1999; 14: 496-502.

• Coppoolse R, Schols AMWJ, Baarends-EM, Mostert R, Akkermans MA, Janssen PP, Wouters EFM. Interval versus continuous training in patients with severe COPD: a randomized clinical trial. Eur Respir J 1999; 14: 258-263.

• Creutzberg EC, Schols MWJ. Anabolic steroids. Curr Opin Clin Nutr Metab Care 1999; 2: 243-253.

• Dentener MA, Bouma MG, Drent M, Wouters EFM, Buurman WA, Measurement of soluble adhesion molecules (sICAM-1 and sE-selectin) in bronchoalveolar lavage fluid, Eur Respir Rev 1999; 66: 113-117

• Drent M. Association of heterozygote glucose-6-phosphate-dehydrogenase deficiency with more advanced disease in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 1999; 16: 108-109.

• Drent M, Jacobs JA; de Vries J, Lamers RJS, Liem IH, Wouters EFM. Does the cellular bronchoalveolar lavage fluid profile reflect the severity of sarcoidosis? Eur respir J 1999; 13: 1338-1344.

• Drent M, Wirnsberger RM, de Vries J, Wouters EFM, Schols AMWJ. Association of fatigue with an acute phase response in sarcoidosis. Eur Respir J 1999; 13: 718-722.

• Ekberg-Jansson A, Larson M, MacNee W, Tunek A, Wahlgren L, Wouters EFM, Larsson S. N-isobutyrylcysteine, a donor of systemic thiols, does not reduce the exacerbation rate in chronic bronchitis. Eur Respir J 1999; 13: 829-834.

• Engelen MPKJ, Schols AMWJ, Lamers RJS, Wouters EFM. Different patterns of chronic tissue wasting among patients with chronic obstructive pulmonary disease. Clin Nutr 1999; 18: 275-280.

• Fransen E, Maessen J, Dentener M, Senden N, Buurman W. Impact of blood transfusions on inflammatory mediator release in patients undergoing cardiac surgery. Chest 1999; 116: 1233-1239.

• Hiki N, Berger D, Dentener MA, Mimura Y, Buurman MA, Prigl C, Seidelmann M, Tsuji E, Kaminishi M, Beger HG. Changes in endotoxin-binding proteins during major elective surgery: Important role for soluble CD14 in regulation of biological activity of systemic endotoxin. Clin Diag Lab Immun 1999; 6: 844-850.

• Jacobs JA, De Brauwer EI, Ramsay G, Cobben NA, Wagenaar SS, van der Ven AJ, Bruggeman CA, Drent M. Detection of non-infectious conditions mimicking pneumonia in the intensive care setting: usefulness of bronchoalveolar fluid cytology. Respir Med 1999;93:571-8.

• Koerts-de Lang E, Hesselink MKC, Drost MR, van der Vusse GJ, Wouters EFM, Schols AMWJ. Enzyme activity of rat tibialis anterior muscle differs between treatment with triamcinolone and prednisolone and nutritional deprivation. Eur J Appl Physiol 1999; 79: 274-279.

• Pennings HJ, Borm PJA, Evelo CTA, Wouters EFM. Changes in levels of catalase and glutathione in erythrocytes of patients with stable asthma, treated with beclomethasone dipropionate. Eur Respir J 1999; 13: 1260-1266.

• Schols AMWJ. TNF-alpha and hypermetabolism in chronic obstructive pulmonary disease. Clin Nutr 1999; 18: 255-257

• Schols AMWJ, Creutzberg EC, Buurman WA, Campfield LA, Saris WHM, Wouters EFM. Plasma leptin is Related to proinflammatory status and dietary intake in patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 1999; 160: 1220-1226.

• Simons JPFHA, Schols AMWJ, Buurman WA, Wouters EFM. Weight loss and low body cell mass in males with lung cancer: relationship with systemic inflammation, acute-phase response, resting energy expenditure, and catabolic and anabolic hormones. Clin Sci 1999; 97: 215-223.

• Simons JPFHA, Schols AMWJ, Westerterp KR, Ten Velde GPM, Wouters EFM. Bioelectrical impedance analysis to assess changes in total body water in patients with cancer. Clin Nutr 1999; 18: 35-39.

• Stappaerts I, Colpaert C, Verbraecken J, Van Marck E, Vermeire P. Granulomatous mastitis as presenting sign of Wegener's granulomatosis. Acta Clin Belg 1999; 54: 207-10.

• van Suylen RJ, Wouters EF, Pennings HJ, Cheriex EC, van Pol PE, Ambergen AW, Vermelis AM, Daemen MJ. The DD genotype of the angiotensin converting enzyme gene is negatively associated with right ventricular hypertrophy in male patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 159: 1791-1795.

• Vreugdenhil ACE, Dentener MA, Snoek AMP, Greve JWM, Buurman WA. Lipopolysaccharide binding protein and serum amyloid a secretion by human intestinal epithelial cells during the acute phase response. J Immun 1999; 163: 2792-2798.

• Wilschut FA, van der Grinten CPM, Lamers RJS, Wouters EFM, Luijendijk SCM. Intrapulmonary gas mixing and the sloping alveolar plateau in COPD patients with macroscopic emphysema. Eur Respir J 1999; 14: 166-171.

• Wirnsberger R, De Vries J, Jansen T, Van Heck G, Wouters E, Drent M. Impairment of quality of life: rheumatoid arthritis versus sarcoidosis. Neth J Med 1999; 54: 86-95.

Miscellaneous:

• Schols AMWJ - for the Working Group on Nutrition and Metabolism, ESICM. Enteral nutrition in intensive care patients: a practical approach. Clin Nutr 1999: 18: 47-56.

• Schols AMWJ, Wouters EFM - for the American Thoracic Society/European Respiratory Society. Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease. A Statement of the American Thoracic Society and European Respiratory Society. Am J Respir Crit Care Med 1999; 159: S1–S40.

1998

• Baarends EM, Van Marken Lichtenbelt WD, Wouters EFM, Schols AMWJ. Body-water compartments measured by bioelectrical impedance spectroscopy in patients with chronic obstructive pulmonary disease. Clin Nutr 1998;17:15-22.

• Baarends EM, Schols AM, Mostert R, Janssen PP, Wouters EF. Analysis of the metabolic and ventilatory response to self-paced 12-minute treadmill walking in patients with severe chronic obstructive pulmonary disease. J Cardiopulm Rehabil 1998; 18: 23-31.

• Baarends EM, Schols AM, Nusmeier CM, van der Grinten CP, Wouters EF. Breathing efficiency during inspiratory threshold loading in patients with chronic obstructive pulmonary disease. Clin Physiol 1998; 18: 235-244.

• Bours GJ, Ketelaars CA, Frederiks CM, Abu Saad HH, Wouters EF. The effects of aftercare on chronic patients and frail elderly patients when discharged from hospital: a systematic review. J Adv Nurs 1998; 27: 1076-1086.

• Calafat J, Janssen H, Tool A, Dentener MA, Knol EF, Rosenberg HF, Egesten A. The bactericidal/permeability-increasing protein (BPI) is present in specific granules of human eosinophils. Blood 1998; 91: 4770-4775.

• Creutzberg EC, Schols AM, Bothmer Quaedvlieg FC, Wesseling G, Wouters EF. Acute effects of nebulized salbutamol on resting energy expenditure in patients with chronic obstructive pulmonary disease and in healthy subjects. Respiration 1998; 65: 375-380.

• Creutzberg EC, Schols AM, Bothmer Quaedvlieg FC, Wouters EF. Prevalence of an elevated resting energy expenditure in patients with chronic obstructive pulmonary disease in relation to body composition and lung function. Eur J Clin Nutr 1998; 52: 396-401.

• Djamin RS, Drent M, Schreurs AJ, Groen EA, Wagenaar SS. Diagnosis of Pneumo cystis carinii pneumonia in HIV-positive patients. Bronchoalveolar lavage vs. bronchial brushing. Acta Cytol 1998; 42: 933-938.

• Drent M, Wirnsberger RM, Breteler MH, Kock LM, de Vries J, Wouters EF. Quality of life and depressive symptoms in patients suffering from sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 1998; 15: 59-66.

• Engelen MP, Schols AM, Heidendal GA, Wouters EF. Dual-energy X-ray absorptio metry in the clinical evaluation of body composition and bone mineral density in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 1998; 68: 1298- 1303.

• van der Ent CK, van der Grinten CP, Meessen NE, Luijendijk SC, Mulder PG, Bogaard JM. Time to peak tidal expiratory flow and the neuromuscular control of expiration. Eur Respir J 1998; 12: 646-652.

• Fransen E, Maessen J, Dentener M, Senden N, Geskes G, Buurman W. Systemic inflammation present in patients undergoing CABG without extracorporeal circulation. Chest 1998; 113: 1290-1295.

• Froon AH, Bonten MJ, Gaillard CA, Greve JW, Dentener MA, de Leeuw PW, Drent M, Stobberingh EE, Buurman WA. Prediction of clinical severity and outcome of ventilator- associated pneumonia. Comparison of simplified acute physiology score with systemic inflammatory mediators. Am J Respir Crit Care Med 1998; 158: 1026-1031.

• Houben MH, Drent M, Jacobs JA, Schrey G, Ramsay G. Multiple organ dysfunction syndrome (MODS) after an intravenous injection of lamp oil (liquid paraffin) [letter]. Intensive Care Med 1998; 24: 87-88.

• Ketelaars CA, Huyer Abu Saad H, Halfens RJ, Schlosser MA, Mostert R, Wouters EF. Effects of specialized community nursing care in patients with chronic obstructive pulmonary disease. Heart Lung 1998; 2: 109-120.

• Koerts De Lang E, Schols AM, Wouters EF, Gayan Ramirez G, Decramer M. Contractile properties and histochemical characteristics of the rat diaphragm after prolonged triamcinolone treatment and nutritional deprivation. J Muscle Res Cell Motil 1998; 19: 549- 555.

• Korn SH, Koerts-De Lang E, Engel GEJ, Arends J, Wouters EFM, Thunnissen FBJM. and ß glucocorticoid receptor mRNA expression in skeletal muscle. Journal of Muscle Research & Cell Motility 1998; 19: 757-765.

• Korn SH, Thunnissen FB, Wesseling GJ, Arends JW, Wouters EF. Glucocorticoid receptor mRNA levels in bronchial epithelial cells of patients with COPD: influence of glucocorticoids. Respir Med 1998; 92: 1102-1109.

• Korn SH, Wouters EF, Wesseling G, Arends JW, Thunnissen FB. Interaction between glucocorticoids and beta2-agonists: alpha and beta glucocorticoid-receptor mRNA expression in human bronchial epithelial cells. Biochem Pharmacol 1998; 56: 1561-1569.

• Lamers RJ, Kemerink GJ, Drent M, van Engelshoven JM. Reproducibility of spirometrically controlled CT lung densitometry in a clinical setting. Eur Respir J 1998; 11: 942-945.

• Langendijk HA, Lamers RJ, ten Velde GP, Sanders DG, de Jong JM, Kessels F, Wouters EF. Is the chest radiograph a reliable tool in the assessment of tumor response after radiotherapy in nonsmall cell lung carcinoma? Int J Radiat Oncol Biol Phys 1998; 41: 1037- 1045.

• Langendijk JA, Tjwa MKT, de Jong JMA, ten Velde GPM, Wouters EFM. Massive haemoptysis after radiotherapy in inoperable non-small cell lung carcinoma: is endobronchial brachytherapy really a risk factor? Radiother Oncol 1998; 49: 175-183.

• Liem IH, Drent M, Antevska E, Lamers RJ, Heidendal GA. Intense muscle uptake of gallium-67 in a patient with sarcoidosis. J Nucl Med 1998; 39: 1605-1607.

• Pennings HJ, Kramer K, Bast A, Buurman WA, Wouters EF. Tumour necrosis factor-alpha induces hyperreactivity in tracheal smooth muscle of the guinea-pig in vitro. Eur Respir J 1998; 12: 45-49.

• Peters FP, Drent M, Van Belle AF. An unusual aspiration. Postgrad Med J 1998;74:639.

• Peters FP, Drent M, Verhaegh M, van Pampus EC, Schouten HC. Myelodysplasia presenting with pulmonary manifestations associated with neutrophilic dermatosis. Ann Hematol 1998; 77: 135-138.

• Peters FP, Thunnissen FB, ten Velde GP. Pulmonary cavitating squamous cell carcinoma. J Clin Oncol 1998; 16: 363-364.

• Pouw EM, Schols AM, Deutz NE, Wouters EF. Plasma and muscle amino acid levels in relation to resting energy expenditure and inflammation in stable chronic obstructi ve pulmonary disease. Am J Respir Crit Care Med 1998; 158: 797-801.

• Pouw EM, Schols AM, van der Vusse GJ, Wouters EF. Elevated inosine monop hosphate levels in resting muscle of patients with stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 157: 453-457.

• Schols AM. Nutritional and metabolic support strategies. Monaldi Arch Chest Dis 1998; 53: 577-581.

• Schols AM, Slangen J, Volovics L, Wouters EF. Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 157: 1791-1797.

• Simons JP, Schols AM, Hoefnagels JM, Westerterp KR, ten Velde GP, Wouters EF. Effects of medroxyprogesterone acetate on food intake, body composition, and resting energy expenditure in patients with advanced, nonhormone-sensitive cancer: a randomized, placebo- controlled trial. Cancer 1998; 82: 553-560.

• Staal van den Brekel AJ, Dentener MA, Drent M, ten Velde GP, Buurman WA, Wouters EF. The enhanced inflammatory response in non-small cell lung carcinoma is not reflected in the alveolar compartment. Respir Med 1998; 92: 76-83.

• Verbraecken J, Willemen M, De Cock W, Van de Heyning P, De Backer W. Relationship between CO2 drive and characteristics of apneas in obstructive and central sleep apnea. Respir Physiol 1998; 114: 185-194.

• Verbraecken J, Willemen M, De Cock W, Coen E, Van de Heyning P, De Backer W. Central sleep apnea after interrupting longterm acetazolamide therapy. Respir Physiol 1998; 112: 59-70.

• Verbraecken J, Willemen M, Geldhof J, De Cock W, Van de Heyning P, De Backer W. [Nasal CPAP in sleep-related respiration disorders: patient profile, therapy compliance and influence of gas exchange and lung function pattern]. Acta Clin Belg 1998; 53: 105-113.

• De Vries J, Drent M, Van Heck GL, Wouters EF. Quality of life in sarcoidosis: a comparison between members of a patient organisation and a random sample. Sarcoidosis Vasc Diffuse Lung Dis 1998; 15: 183-188.

• Wirnsberger RM, de Vries J, Breteler MH, van Heck GL, Wouters EF, Drent M. Evaluation of quality of life in sarcoidosis patients. Respir Med 1998; 92: 750-756.

• Wirnsberger RM, de Vries J, Wouters EF, Drent M. Clinical presentation of sarcoidosis in The Netherlands an epidemiological study. Neth J Med 1998; 53: 53-60.

Miscellaneous:

• Schols AMWJ - for the Working Group on Nutrition and Metabolism, ESICM. Enteral nutrition in intensive care patients: a practical approach. Int Care Med 1998; 24: 848-859.

1997

• Baarends EM, Schols AM, Akkermans MA, Wouters EF. Decreased mechanical efficiency in clinically stable patients with COPD. Thorax 1997; 52: 981-986.

• Baarends EM, Schols AM, Mostert R, Wouters EF. Peak exercise response in relation to tissue depletion in patients with chronic obstructive pulmonary disease. Eur Respir J 1997; 10: 2807-2813.

• Baarends EM, Schols AM, Pannemans DL, Westerterp KR, Wouters EF. Total free living energy expenditure in patients with severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1997; 155: 549-554.

• Baarends EM, Schols AM, van Marken Lichtenbelt WD, Wouters EF. Analysis of body water compartments in relation to tissue depletion in clinically stable patients with chronic obstructive pulmonary disease. Am J Clin Nutr 1997; 65: 88-94.

• Baarends EM, Schols AM, Westerterp KR, Wouters EF. Total daily energy expendi ture relative to resting energy expenditure in clinically stable patients with COPD. Thorax 1997; 52: 780-785.

• Bonten MJ, Froon AH, Gaillard CA, Greve JW, de Leeuw PW, Drent M, Stobbe ringh EE, Buurman WA. The systemic inflammatory response in the development of ventilator-associated pneumonia. Am J Respir Crit Care Med 1997; 156: 1105-1113.

• Boudewyns A, Willemen M, De Cock W, Verbraecken J, Coen E, Wagemans M, De Backer W, Van de Heyning PH. Does socially disturbing snoring and/or excessive daytime sleepiness warrant polysomnography? Clin Otolaryngol 1997; 22: 403-407.

• Bouma MG, Jeunhomme TM, Boyle DL, Dentener MA, Voitenok NN, van den Wildenberg FA, Buurman WA. Adenosine inhibits neutrophil degranulation in activated human whole blood: involvement of adenosine A2 and A3 receptors. J Immunol 1997; 158: 5400-5408.

• Bouma M, Maessen J, Weerwind P, Dentener M, Fransen E, de Jong D, Buurman W. Release of lipopolysaccharide toxicity-modulating proteins in patients undergoing cardiopulmonary bypass using noncoated and heparin-coated extracorporeal circuits - A clinical pilot study. Chest 1997; 111: 577-583.

• Cobben NA, Drent M, Schols AM, Lamers RJ, Wouters EF, Van Dieijen Visser MP. Serum lactate dehydrogenase and its isoenzyme pattern in ex-coalminers. Respir Med 1997; 91: 616-623.

• Cobben NA, van Belle AF, Pennings HJ, Mulder PG, van Dieijen Visser MP, Wouters EF, Drent M. Diagnostic value of lactate dehydrogenase isoenzyme pattern in pleural effusions. Eur J Clin Chem Clin Biochem 1997; 35: 523-528.

• Cuijpers CE, Wesseling GJ, Kessels AG, Swaen GM, Mertens PL, de Kok ME, Broer J, Sturmans F, Wouters EF. Low diagnostic value of respiratory impedance measure ments in children. Eur Respir J 1997; 10: 88-93.

• Dentener MA, Francot GJ, Hiemstra PS, Tool AT, Verhoeven AJ, Vandenabeele P, Buurman WA. Bactericidal/permeability-increasing protein release in whole blood ex vivo: strong induction by lipopolysaccharide and tumor necrosis factor-alpha. J Infect Dis 1997; 175: 108-117.

• Drent M, Grutters JC, Mulder PG, van Velzen Blad H, Wouters EF, van den Bosch JM. Is the different T helper cell activity in sarcoidosis and extrinsic allergic alveolitis also reflected by the cellular bronchoalveolar lavage fluid profile? Sarcoidosis Vasc Diffuse Lung Dis 1997; 14: 31-38.

• Drent M, Peters FP, Jacobs JA, Maassen van de Brink KI, Wagenaar SS, Wouters EF. Pulmonary infiltration associated with myelodysplasia. Ann Oncol 1997; 8: 905-909.

• Fredrix EW, Staal van den Brekel AJ, Wouters EF. Energy balance in nonsmall cell lung carcinoma patients before and after surgical resection of their tumors. Cancer 1997; 79: 717-723.

• Hochstenbag MM, Heidendal GA, Wouters EF, ten Velde GP. In-111 octreotide imaging in staging of small cell lung cancer. Clin Nucl Med 1997; 22: 811-816.

• Ketelaars CA, Abu Saad HH, Schlosser MA, Mostert R, Wouters EF. Long-term outcome of pulmonary rehabilitation in patients with COPD. Chest 1997; 112: 363-369.

• Korn SH, Wouters EF, Wesseling G, Arends JW, Thunnissen FB. In vitro and in vivo modulation of alpha- and beta-glucocorticoid-receptor mRNA in human bronchial epithelium. Am J Respir Crit Care Med 1997; 155: 1117-1122.

• Meessen NE, van der Grinten CP, Luijendijk SC, Folgering HT. Breathing pattern during bronchial challenge in humans. Eur Respir J 1997; 10: 1059-1063.

• Pasker HG, Peeters M, Genet P, Clement J, Nemery B, Van de Woestijne KP. Short- term ventilatory effects in workers exposed to fumes containing zinc oxide: comparison of forced oscillation technique with spirometry. Eur Respir J 1997; 10: 1523-1529.

• Pennings HJ, Wouters EF. Effect of inhaled beclomethasone dipropionate on isocapnic hyperventilation with cold air in asthmatics, measured with forced oscillation technique. Eur Respir J 1997; 10: 665-671.

• van de Pol M, ten Velde GP, Wilmink JT, Volovics A, Twijnstra A. Efficacy and safety of prophylactic cranial irradiation in patients with small cell lung cancer. J Neurooncol 1997; 35: 153-160.

• van der Poll T, Coyle SM, Levi M, Jansen PM, Dentener M, Barbosa K, Buurman WA, Hack E, ten Cate JW, Agosti JM, Lowry SF. Effect of a recombinant Dimeric Tumor Necrosis Factor Receptor on inflammatory response to intravenous endotoxin in normal humans. Blood 1997; 89: 3727-3734.

• van der Poll T, Levi M, Dentener M, Jansen PM, Coyle SM, Braxton CC, Buurman WA, Hack CE, ten Cate JW, Lowry SF. Epinephrine exerts anticoagulant effects during human endotoxemia. J Exp Med 1997; 185: 1143-1148.

• Riley M, Maehara K, Porszasz J, Engelen MP, Bartstow TJ, Tanaka H, Wasserman K. Association between the anaerobic threshold and the break-point in the double pro duct/work rate relationship. Eur J Appl Physiol 1997; 75: 14-21.

• Riley MS, Porszasz J, Miranda J, Engelen MP, Brundage B, Wasserman K. Exhaled nitric oxide during exercise in primary pulmonary hypertension and pulmonary fibrosis. Chest 1997; 111: 44-50.

• Schols AM. Nutrition and outcome in chronic respiratory disease. Nutrition 1997; 13: 161-163.

• Simons JP, Schols AM, Campfield LA, Wouters EF, Saris WH. Plasma concentrati on of total leptin and human lung-cancer-associated cachexia. Clin Sci Colch 1997; 93: 273- 277.

• Staal van den Brekel AJ, Schols AM, Dentener MA, ten Velde GP, Buurman WA, Wouters EF. Metabolism in patients with small cell lung carcinoma compared with patients with non-small cell lung carcinoma and healthy controls. Thorax 1997; 52: 338-341.

• Staal van den Brekel AJ, Schols AM, Dentener MA, ten Velde GP, Buurman WA, Wouters EF. The effects of treatment with chemotherapy on energy metabolism and inflammatory mediators in small-cell lung carcinoma. Br J Cancer 1997; 76: 1630-1635.

• Vermeeren MA, Schols AM, Wouters EF. Effects of an acute exacerbation on nutritional and metabolic profile of patients with COPD. Eur Respir J 1997; 10: 2264-2269.

• Verstraeten E, Cluydts R, Verbraecken J, De Roeck J. Psychomotor and cognitive performance in nonapneic snorers: preliminary findings. Percept Mot Skills 1997; 84: 1211- 1222.

• Wilschut FA, Cobben NA, Thunnissen FB, Lamers RJ, Wouters EF, Drent M. Recurrent respiratory distress associated with carbamazepine overdose. Eur Respir J 1997; 10: 2163-2165.

• Wirnsberger RM, Drent M, Hekelaar N, Breteler MH, Drent S, Wouters EF, Dekhuijzen PN. Relationship between respiratory muscle function and quality of life in sarcoidosis. Eur Respir J 1997; 10: 1450-1455.

• Wouters EFM, Schols AMWJ. Nutritional depletion in COPD. Eur Respir Rev 1997;7(42):60-65.

Miscellaneous:

• ten Velde GP - for the EORTC Lung Cancer Cooperative Group. Role of recombinant interferon-gamma maintenance in responding patients with small cell lung cancer. A randomised phase III study of the EORTC Lung Cancer Cooperative Group. Eur J Cancer 1997; 33: 1759-1766.

• Wouters EFM - for the Rehabilitation and chronic care scientific group of the European Respiratory Society. Selection criteria and programmes for pulmonary rehabilitation in COPD patients. Eur Respir J 1997;10:744-757.

1996

• Boers JE, ten Velde GP, Thunnissen FB. P53 in squamous metaplasia: a marker for risk of respiratory tract carcinoma. Am J Respir Crit Care Med 1996; 153: 411-416.

• Cobben NA, Drent M, Jonkers M, Wouters EF, Vaneechoutte M, Stobberingh EE. Outbreak of severe Pseudomonas aeruginosa respiratory infections due to contaminated nebulizers. J Hosp Infect 1996; 33: 63-70.

• Dentener MA, Francot GJ, Buurman WA. Bactericidal/permeability-increasing protein, a lipopolysaccharide-specific protein on the surface of human peripheral blood monocytes. J Infect Dis 1996; 173: 252-255.

• Drent M, Cobben NA, Henderson RF, Jacobs JA, Wouters EF, van Dieijen Visser MP. BAL fluid LDH activity and LDH isoenzyme pattern in lipoid pneumonia caused by an intravenous injection of lamp oil. Eur Respir J 1996; 9: 2416-2418.

• Drent M, Cobben NA, Henderson RF, Wouters EF, van Dieijen Visser M. Useful ness of lactate dehydrogenase and its isoenzymes as indicators of lung damage or inflammati on. Eur Respir J 1996; 9: 1736-1742.

• Drent M, van Nierop MA, Gerritsen FA, Wouters EF, Mulder PG. A computer program using BALF-analysis results as a diagnostic tool in interstitial lung diseases. Am J Respir Crit Care Med 1996; 153: 736-741.

• Hochstenbag MM, Snoep G, Cobben NA, Schols AM, Thunnissen FB, Wouters EF, ten Velde GP. Detection of bone marrow metastases in small cell lung cancer. Comparison of magnetic resonance imaging with standard methods. Eur J Cancer 1996; 32a: 779-782.

• Ketelaars CA, Schlosser MA, Mostert R, Huyer Abu Saad H, Halfens RJ, Wouters EF. Determinants of health-related quality of life in patients with chronic obstructive pulmonary disease. Thorax 1996; 51: 39-43.

• de Kok ME, Mertens PL, Cuijpers CE, Swaen GM, Wesseling GJ, Broer J, Sturmans F, Wouters EF. The rate of respiratory symptoms among primary school children in two Dutch regions. Eur J Pediatr 1996; 155: 506-511.

• van Krugten M, Cobben NA, Lamers RJ, van Dieijen Visser MP, Wagenaar SS, Wouters EF, Drent M. Serum LDH: a marker of disease activity and its response to therapy in idiopathic pulmonary fibrosis. Neth J Med 1996; 48: 220-223.

• Meessen NE, van der Grinten CP, Luijendijk SC, Folgering HT. Histamine induced bronchoconstriction and end tidal inspiratory activity in man. Thorax 1996; 51: 1192-1198.

• Pasker HG, Schepers R, Clement J, Van de Woestijne KP. Total respiratory impedance measured by means of the forced oscillation technique in subjects with and without respiratory complaints. Eur Respir J 1996; 9: 131-139.

• van de Pol M, van Oosterhout AG, Wilmink JT, ten Velde GP, Twijnstra A. MRI in detection of brain metastases at initial staging of small-cell lung cancer. Neuroradiology 1996; 38: 207-210.

• Schols AM, Buurman WA, Staal van den Brekel AJ, Dentener MA, Wouters EF. Evidence for a relation between metabolic derangements and increased levels of inflammato ry mediators in a subgroup of patients with chronic obstructive pulmonary disease. Thorax 1996; 51: 819-824.

• Simons JP, Aaronson NK, Vansteenkiste JF, ten Velde GP, Muller MJ, Drenth BM, Erdkamp FL, Cobben EG, Schoon EJ, Smeets JB, Schouten HC, Demedts M, Hillen HF, Blijham GH, Wouters EF. Effects of medroxyprogesterone acetate on appetite, weight, and quality of life in advanced-stage non-hormone-sensitive cancer: a placebo-controlled multicenter study. J Clin Oncol 1996; 14: 1077-1084.

• Staal van den Brekel AJ, Thunnissen FB, Buurman WA, Wouters EF. Expression of E-selectin, intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in non-small-cell lung carcinoma. Virchows Arch 1996; 428: 21-27.

• van Oosterhout AG, van de Pol M, ten Velde GP, Twijnstra A. Neurologic disorders in 203 consecutive patients with small cell lung cancer. Results of a longitudinal study. Cancer 1996; 77: 1434-1441.

• Vansteenkiste JF, Simons JP, Wouters EF, Demedts MG. Hormonal treatment in advanced non-small cell lung cancer: fact or fiction? Eur Respir J 1996; 9: 1707-1712.

• Verstraeten E, Cluydts R, Verbraecken J, De Roeck J. Neuropsychological functio ning and determinants of morning alertness in patients with obstructive sleep apnea syndro me. J Int Neuropsychol Soc 1996; 2: 306-314.

Miscellaneous:

• Wouters EFM - for the International Primary Pulmonary Hypertension Study Group. Appetite-suppressant drugs and the risk of primary pulmonary hypertension. New Engl J Med 1996;335(9):609-616.

1995

• Baarends EM, Schols AM, Slebos DJ, Mostert R, Janssen PP, Wouters EF. Metabolic and ventilatory response pattern to arm elevation in patients with COPD and healthy age- matched subjects. Eur Respir J 1995; 8: 1345-1351.

• Cuijpers CE, Swaen GM, Wesseling G, Hoek G, Sturmans F, Wouters EF. Acute respiratory effects of low level summer smog in primary school children. Eur Respir J 1995; 8: 967-975.

• Cuijpers CE, Swaen GM, Wesseling G, Sturmans F, Wouters EF. Adverse effects of the indoor environment on respiratory health in primary school children. Environ Res 1995; 68: 11-23.

• DeBacker WA, Verbraecken J, Willemen M, Wittesaele W, DeCock W, Van deHeyning P. Central apnea index decreases after prolonged treatment with acetazolamide. Am J Respir Crit Care Med 1995; 151: 87-91.

• Dentener MA, Francot GJ, Smit FT, Froon AH, Pennings HJ, Wouters EF, Buurman WA. Presence of bactericidal/permeability-increasing protein in disease: detection by ELISA. J Infect Dis 1995; 171: 739-743.

• Drent M, van Rens MT, Wagenaar SS, de Jongh BM, van Velzen Blad H, van den Bosch JM. Invasive aspergillosis after bilateral lung transplantation in cystic fibrosis. Respir Med 1995; 89: 449-451.

• Engelen MP, Casaburi R, Rucker R, Carithers E. Contribution of the respiratory muscles to the lactic acidosis of heavy exercise in COPD. Chest 1995; 108: 1246-1251.

• van Esser JW, van Belle AF, Lamers RJ, Thunnissen FB, Wesseling GJ, Wouters EF. A young woman with cough and chest pain. Eur Respir J 1995; 8: 664-666.

• Froon AH, Dentener MA, Greve JW, Ramsay G, Buurman WA. Lipopolysaccharide toxicity-regulating proteins in bacteremia. J Infect Dis 1995; 171: 1250-1257.

• van der Grinten CP, Meessen NE, Luijendijk SC. Vagal cooling and the origin of pulmonary reflexes in cats. Adv Exp Med Biol 1995; 393: 67-72.

• Hamans E, Boudewyns A, De Backer W, Coen E, Verbraecken J, Van de Heyning P. Sleep related breathing disorders: the respiratory control system and its instability during sleep. Acta Otorhinolaryngol Belg 1995; 49: 45-51.

• Lamers RJ, Hochstenbag MM, van Belle AF, Wouters EF. Unilateral hilar mass. Chest 1995; 108: 1444-1446.

• Langendijk JA, Thunnissen FB, Lamers RJ, de Jong JM, ten Velde GP, Wouters EF. The prognostic significance of accumulation of p53 protein in stage III non-small cell lung cancer treated by radiotherapy. Radiother Oncol 1995; 36: 218-224.

• Meeseen NE, van der Grinten CP, Folgering HT, Luijendijk SC. Histamine-induced end-tidal inspiratory activity and lung receptors in cats. Eur Respir J 1995; 8: 2094-2103.

• van Oosterhout AG, Boon PJ, Houx PJ, ten Velde GP, Twijnstra A. Follow-up of cognitive functioning in patients with small cell lung cancer. Int J Radiat Oncol Biol Phys 1995; 31: 911-914.

• Sanders DG, Lamers RJ, Wesseling G. Left apical pulmonary mass. Chest 1995; 108: 269-270.

• Schols AM, Soeters PB, Mostert R, Pluymers RJ, Wouters EF. Physiologic effects of nutritional support and anabolic steroids in patients with chronic obstructive pulmonary disease. A placebo-controlled randomized trial. Am J Respir Crit Care Med 1995; 152: 1268- 1274.

• Schols AMWJ, Wouters EFM. Nutritional considerations in the treatment of chronic obstructive pulmonary disease. Clin Nutr 1995;14:64-73.

• Schrikker AC, Wesenhagen H, Luijendijk SC. Intrapulmonary gas mixing and dead space in artificially ventilated dogs. Pflugers Arch 1995; 430: 862-870.

• Simons JP, Schols AM, Westerterp KR, ten Velde GP, Wouters EF. The use of bioelectrical impedance analysis to predict total body water in patients with cancer cachexia. Am J Clin Nutr 1995; 61: 741-745.

• Staal van den Brekel AJ, Dentener MA, Schols AM, Buurman WA, Wouters EF. Increased resting energy expenditure and weight loss are related to a systemic inflammatory response in lung cancer patients. J Clin Oncol 1995; 13: 2600-2605.

• Tinnemans MM, Lenders MH, ten Velde GP, Blijham GH, Ramaekers FC, Schutte B. S-phase arrest of nutrient deprived lung cancer cells. Cytometry 1995; 19: 326-333.

• Tinnemans MM, Lenders MH, ten Velde GP, Ramaekers FC, Schutte B. Alterations in cytoskeletal and nuclear matrix-associated proteins during apoptosis. Eur J Cell Biol 1995; 68: 35-46.

• Tinnemans MM, Lenders MH, ten Velde GP, Wagenaar SS, Blijham GH, Ramae kers FC, Schutte B. Evaluation of proliferation parameters in in vivo bromodeoxyuridine labelled lung cancers. Virchows Arch 1995; 427: 295-301.

• Verbraecken J, De Backer W, Willemen M, De Cock W, Wittesaele W, Van de H. Chronic CO2 drive in patients with obstructive sleep apnea and effect of CPAP. Respir Physiol 1995; 101: 279-287.

• Versluis PJ, Lamers RJ, van Belle AF. Primary malignant lymphoma of the heart: CT and MRI features. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 1995; 162: 533- 534.

1994

• von Asmuth EJ, Dentener MA, Ceska M, Buurman WA. IL-6, IL-8 and TNF production by cytokine and lipopolysaccharide-stimulated human renal cortical epithelial cells in vitro. Eur Cytokine Netw 1994; 5: 301-310.

• Bonten MJ, Gaillard CA, Wouters EF, van Tiel FH, Stobberingh EE, van der Geest S. Problems in diagnosing nosocomial pneumonia in mechanically ventilated patients: a review. Crit Care Med 1994; 22: 1683-1691.

• Cuijpers CE, Swaen GM, Wesseling G, Wouters EF. Acute respiratory effects of summer smog in primary school children. Toxicol Lett 1994; 72: 227-235.

• Cuijpers CE, Wesseling GJ, Swaen GM, Sturmans F, Wouters EF. Asthma-related symptoms and lung function in primary school children. J Asthma 1994; 31: 301-312.

• Cuijpers CEJ, Wesseling G, Swaen GMH, Wouters EFM. Height and gender related impedance values in primary schoolchildren. Eur Respir Rev 1994;4(19):150-154.

• Dentener MA, Smit FT, Francot GJ, Buurman WA. Characterization of two monoclonal antibodies directed against bactericidal/permeability-increasing protein. J Infect Dis 1994; 170: 1483-1489.

• Dentener MA, Von Asmuth EJ, Francot GJ, Buurman WA. Interaction between CD14 lipopolysaccharide binding protein and bactericidal/permeability-increasing protein during lipopolysaccharide-induced cell activation. Prog Clin Biol Res 1994; 388: 59-70.

• Drent M, Wagenaar SS, Mulder PH, van Velzen Blad H, Diamant M, van den Bosch JM. Bronchoalveolar lavage fluid profiles in sarcoidosis, tuberculosis, and non-Hodgkin's and Hodgkin's disease. An evaluation of differences. Chest 1994; 105: 514-519.

• Engelen MP, Schols AM, Baken WC, Wesseling GJ, Wouters EF. Nutritional depletion in relation to respiratory and peripheral skeletal muscle function in out-patients with COPD. Eur Respir J 1994; 7: 1793-1797.

• Jorna TH, Borm PJ, Koiter KD, Slangen JJ, Henderson PT, Wouters EF. Respiratory effects and serum type III procollagen in potato sorters exposed to diatomaceous earth. Int Arch Occup Environ Health 1994; 66: 217-222.

• Jorna THJM, Borm PJA, Wesseling G, Wouters EFM. Application of the forced oscillation technique (FOT) in different occupational settings. Eur Respir Rev 1994;4(19):155-158.

• Jorna TH, Borm PJ, Valks J, Houba R, Wouters EF. Respiratory symptoms and lung function in animal feed workers. Chest 1994; 106: 1050-1055.

• Jorna TH, Schins RP, Lenaerts L, Derhaag TJ, Wouters EF, Borm PJ. Airflow obstruction and monocyte TNF release in coal workers. Exp Lung Res 1994; 20: 421-431.

• Ketelaars CA. Using the RUMBA requirements in developing criteria. Nurs Qual Connect 1994; 4: 7.

• Ketelaars CA, Saad HH, Halfens RJ, Wouters EF. Process standards of nursing care for patients with COPD: validation of standards and criteria by the Delphi technique. J Nurs Care Qual 1994; 9: 78-86.

• Lamers RJ, Schins RP, Wouters EF, van Engelshoven JM. High-resolution compu ted tomography of the lungs in coal miners with a normal chest radiograph. Exp Lung Res 1994; 20: 411-419.

• Lamers RJ, Thelissen GR, Kessels AG, Wouters EF, van Engelshoven JM. Chronic obstructive pulmonary disease: evaluation with spirometrically controlled CT lung densito metry. Radiology 1994; 193: 109-113.

• Leeuwenberg JF, Dentener MA, Buurman WA. Lipopolysaccharide LPS-mediated soluble TNF receptor release and TNF receptor expression by monocytes. Role of CD14, LPS binding protein, and bactericidal/permeability-increasing protein. J Immunol 1994; 152: 5070-5076.

• Meessen NE, van der Grinten CP, Luijendijk SC, Folgering HT. Continuous negative airway pressure increases tonic activity in diaphragm and intercostal muscles in humans. J Appl Physiol 1994; 77: 1256-1262.

• van de Pol M, Twijnstra A, ten Velde GP, Menheere PP. Neuron-specific enolase as a marker of brain metastasis in patients with small-cell lung carcinoma. J Neurooncol 1994; 19: 149-154.

• Staal van den Brekel AJ, Schols AM, ten Velde GP, Buurman WA, Wouters EF. Analysis of the energy balance in lung cancer patients. Cancer Res 1994; 54: 6430-6433.

• ten Velde GP, Thunnissen FB, van Engelshoven JM, Wouters EF. A solitary pulmonary nodule due to eosinophilic granuloma. Eur Respir J 1994; 7: 1539-1540.

• van Marken Lichtenbelt WD, Westerterp KR, Wouters L, Luijendijk SC. Validation of bioelectrical-impedance measurements as a method to estimate body-water compartments. Am J Clin Nutr 1994; 60: 159-166.

• Verbraecken J, De Backer W, De Cock W, Wittesaele W, Van de Heyning P. The usefulness of an alternative EEG scoring system in obstructive sleep apnea. Acta Otorhino laryngol Belg 1994; 48: 27-35.

• Wouters EF, Jorna TH, Westenend M. Respiratory effects of coal dust exposure: clinical effects and diagnosis. Exp Lung Res 1994; 20: 385-394.

• Wouters EFM (amongst others) The International Primary Pulmonary Hypertension Study (IPPHS). The IPPHS Group.Chest 1994;105(2):37S-41S.

1993

• von Asmuth EJ, Dentener MA, Bazil V, Bouma MG, Leeuwenberg JF, Buurman WA. Anti-CD14 antibodies reduce responses of cultured human endothelial cells to endo toxin. Immunology 1993; 80: 78-83.

• Cuijpers CE, Wesseling G, Swaen GM, Wouters EF. Frequency dependence of oscillatory resistance in healthy primary school children. Respiration 1993; 60: 149-154.

• Dentener MA, Bazil V, Von Asmuth EJ, Ceska M, Buurman WA. Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-alpha, IL-6 and IL-8 release by human monocytes and alveolar macrophages. J Immunol 1993; 150: 2885-2891.

• Dentener MA, Von Asmuth EJ, Francot GJ, Marra MN, Buurman WA. Antagonistic effects of lipopolysaccharide binding protein and bactericidal/permeability-increasing protein on lipopolysaccharide-induced cytokine release by mononuclear phagocytes. Competition for binding to lipopolysaccharide. J Immunol 1993; 151: 4258-4265.

• Drent M, Mulder PG, Wagenaar SS, Hoogsteden HC, van Velzen Blad H, van den Bosch JM. Differences in BAL fluid variables in interstitial lung diseases evaluated by discriminant analysis. Eur Respir J 1993; 6: 803-810.

• Drent M, van Velzen Blad H, Diamant M, Hoogsteden HC, van den Bosch JM. Relationship between presentation of sarcoidosis and T lymphocyte profile. A study in bronchoalveolar lavage fluid. Chest 1993; 104: 795-800.

• Drent M, van Velzen Blad H, Diamant M, Wagenaar SS, Donckerwolck Bogaert M, van den Bosch JM. Differential diagnostic value of plasma cells in bronchoalveolar lavage fluid. Chest 1993; 103: 1720-1724.

• Drent M, van Velzen Blad H, Diamant M, Wagenaar SS, Hoogsteden HC, van den Bosch JM. Bronchoalveolar lavage in extrinsic allergic alveolitis: effect of time elapsed since antigen exposure. Eur Respir J 1993; 6: 1276-1281.

• Drent M, Wagenaar S, van Velzen Blad H, Mulder PG, Hoogsteden HC, van den Bosch JM. Relationship between plasma cell levels and profile of bronchoalveolar lavage fluid in patients with subacute extrinsic allergic alveolitis. Thorax 1993; 48: 835-839.

• Meessen NE, van der Grinten CP, Folgering HT, Luijendijk SC. Tonic activity in inspiratory muscles during continuous negative airway pressure. Respir Physiol 1993; 92: 151-166.

• Schols AM, Deutz NE, Mostert R, Wouters EF. Plasma amino acid levels in patients with chronic obstructive pulmonary disease. Monaldi Arch Chest Dis 1993; 48: 546-548.

• Schols AM, Soeters PB, Dingemans AM, Mostert R, Frantzen PJ, Wouters EF. Prevalence and characteristics of nutritional depletion in patients with stable COPD eligible for pulmonary rehabilitation. Am Rev Respir Dis 1993; 147: 1151-1156.

• Schrikker AC, Wesenhagen H, Luijendijk SC. Intrapulmonary gas mixing and pulmonary gas exchange in artificially ventilated dogs. Pflugers Arch 1993; 425: 16-21.

• Tinnemans MM, Schutte B, Lenders MH, Ten Velde GP, Ramaekers FC, Blijham GH. Cytokinetic analysis of lung cancer by in vivo bromodeoxyuridine labelling. Br J Cancer 1993; 67: 1217-1222.

• Wesseling G, Brummer RJ, Wouters EF, ten Velde GP. Gastric asthma? No change in respiratory impedance during intraesophageal acidification in adult asthmatics. Chest 1993; 104: 1733-1736.

• Wesseling GJ, Vanderhoven Augustin IM, Wouters EF. Forced oscillation technique and spirometry in cold air provocation tests. Thorax 1993; 48: 254-259.

• Wouters EF, Schols AM. Metabolic support and energy supply in chronic respirato ry failure. Monaldi Arch Chest Dis 1993; 48: 530-534.

• Wouters EF, Schols AM. Prevalence and pathophysiology of nutritional depletion in chronic obstructive pulmonary disease. Respir Med 1993; 87: 45-47.

1992

• van Belle AF, Wesseling GJ, Penn OC, Wouters EF. Postoperative pulmonary function abnormalities after coronary artery bypass surgery. Respir Med 1992; 86: 195-199.

• Drent M, Gelissen JP, Ascoop CA, Wagenaar SS, van den Bosch JM. Mediastinal lymph node enlargement as a result of mitral valve stenosis. Chest 1992; 102: 1269-1271.

• van der Grinten CP, Schoute E, de Vries WR, Luijendijk SC. Conventional versus slug CO2 loading and the control of breathing in anaesthetized cats. J Physiol Lond 1992; 445: 487-498.

• van der Grinten CP, de Vries WR, Luijendijk SC. Vagally mediated modification of inspiratory activity by changes in airway pressure. Respir Physiol 1992; 90: 159-172.

• Habets JM, van Oosterhout AG, ten Velde GP, Wilmink JT, Twijnstra A. Diagnostic value of CT in the detection of brain metastasis in small cell lung cancer patients. J Belge Radiol 1992; 75: 179-181.

• Pouwels HM, Janevski BK, Penn OC, Sie HT, ten Velde GP. Systemic to pulmonary vascular malformation. Eur Respir J 1992; 5: 1288-1291.

• Schols AM, Schoffelen PF, Ceulemans H, Wouters EF, Saris WH. Measurement of resting energy expenditure in patients with chronic obstructive pulmonary disease in a clinical setting. JPEN J Parenter Enteral Nutr 1992; 16: 364-368.

• Six DP, de Vries WR, Luijendijk SC. Collateral ventilation and the sloping alveolar plateaus of He and SF6: a model study. Respir Physiol 1992; 90: 145-158.

• Wesseling G, Mostert R, Wouters EF. A comparison of the effects of anticholinergic and beta 2-agonist and combination therapy on respiratory impedance in COPD. Chest 1992; 101: 166-173.

• Wesseling G, Quaedvlieg FC, Wouters EF. Oscillatory mechanics of the respiratory system in neuromuscular disease. Chest 1992; 102: 1752-1757.

• Wesseling GJ, Wouters EF. Respiratory impedance measurements in a dose- response study of isocapnic hyperventilation with cold air. Respiration 1992; 59: 259-264.

• Wesseling GJ, Wouters EF. Analysis of respiratory impedance characteristics in chronic bronchitis. Respiration 1992; 59: 81-88.

• Wouters EF, Landser FJ, Polko AH, Visser BF. Impedance measurement during air and helium-oxygen breathing before and after salbutamol in COPD patients. Clin Exp Pharmacol Physiol 1992; 19: 95-101.

1991

• Brutel de la Riviere T, Thunnissen FB, ten Velde GP. Unusual clinical presentation of bronchioloalveolar carcinoma in 2 cases [letter]. Eur J Cancer 1991; 27: 1332.

• Fredrix EW, Soeters PB, Wouters EF, Deerenberg IM, von Meyenfeldt MF, Saris WH. Effect of different tumor types on resting energy expenditure. Cancer Res 1991; 51: 6138-6141.

• Fredrix EW, Wouters EF, Soeters PB, van der Aalst AC, Kester AD, von Meyenfeldt MF, Saris WH. Resting energy expenditure in patients with non-small cell lung cancer. Cancer 1991; 68: 1616-1621.

• van der Grinten CP, de Vries WR, Luijendijk SC. Vagal amplification of phrenic nerve activity at different levels of ventilation in spontaneously breathing cats. Eur J Appl Physiol 1991; 62: 49-55.

• van der Kooij AM, Luijendijk SC. Longitudinal dispersion in model of central airways during high-frequency ventilation. Respir Physiol 1991; 84: 13-29.

• Luijendijk SC, de Vries WR, Zwart A. Collateral ventilation by diffusion across the alveolar walls and the exchange of inert gases in the lung. Eur Respir J 1991; 4: 1228-1236.

• Schols AM, Fredrix EW, Soeters PB, Westerterp KR, Wouters EF. Resting energy expenditure in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 1991; 54: 983-987.

• Schols AMWJ, Mostert R, Cobben N, Soeters PB, Wouters EFM. Transcutaneous oxygen saturation and carbon dioxide tension during meals in patients with chronic obstructive pulmonary disease. Chest 1991;100(5):1287-1292.

• Schols AM, Mostert R, Soeters PB, Wouters EF. Body composition and exercise performance in patients with chronic obstructive pulmonary disease. Thorax 1991; 46: 695-699.

• Schols AM, Soeters PB, Mostert R, Saris WH, Wouters EF. Energy balance in chronic obstructive pulmonary disease. Am Rev Respir Dis 1991; 143: 1248-1252.

• Schols AM, Wouters EF, Soeters PB, Westerterp KR. Body composition by bioelectrical-impedance analysis compared with deuterium dilution and skinfold anthropo metry in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 1991; 53: 421-424.

• Six DP, de Vries WR, Luijendijk SC. Alveolar sacs and the expirograms of He and SF6: a model study. Comput Biomed Res 1991; 24: 321-331.

• Six DP, de Vries WR, Luijendijk SC. Sloping alveolar plateaus of He and SF6 measured in excised cat lungs ventilated at constant volume by pressure changes. Respir Physiol 1991; 83: 277-293.

• van Steen AW, van Duinen KA, Drent M. Victims of traumatic events. Manage ment of psychological trauma in the emergency department. Tvz 1991; 29: 582-585.

• ten Velde GP, Havenith MG, Volovics A, Bosman FT. Prognostic significance of basement membrane deposition in operable squamous cell carcinomas of the lung. Cancer 1991; 67: 3001-3005.

• ten Velde GP, Thunnissen FB. Anterior mediastinal tumor of 30 years' duration. Chest 1991; 100: 869-870.

• Wesseling GJ, Quaedvlieg M, Wouters EF. Inhaled budesonide in chronic bronchi tis. Effects on respiratory impedance. Eur Respir J 1991; 4: 1101-1105.

• Wouters EFM. Data interpretation of total respiratory impedance measurement in clinical practice. Eur Resp Rev 1991;1(3):216-217.

1990

• Fredrix EWHM, Soeters PB, Wouters EFM, Deerenberg IM, Von Meyenfeldt MF, Saris WHM. Energy balance in relation to cancer cachexia. Clin Nutr 1990;9:319-324.

• Fredrix EW, Saris WH, Soeters PB, Wouters EF, Kester AD, von Meyenfeldt MF, Westerterp KR. Estimation of body composition by bioelectrical impedance in cancer patients. Eur J Clin Nutr 1990; 44: 749-752.

• Pouwels HM, Smeets JL, Cheriex EC, Wouters EF. Pulmonary hypertension and fenfluramine. Eur Respir J 1990; 3: 606-607.

• Quaedvlieg M, Wouters EF. Early airway obstruction in young asymptomatic smokers after cold-air challenge. Respiration 1990; 57: 299-303.

• Soeters PB, Von Meyenfeldt MF, Meijerink WJHJ, Fredrix EWHM, Wouters EFM, Schols AMWJ. Serum albumin and mortality. Lancet 1990;335:348.

• Schols AMWJ, Dingemans AMC, Soeters PB, Wouters EFM. Within day variation of bioelectrical resistance measurements in patients with chronic obstructive pulmonary disease. Clin Nutr 1990;9:266-271.

• Swerts PM, Kretzers LM, Terpstra Lindeman E, Verstappen FT, Wouters EF. Exercise reconditioning in the rehabilitation of patients with chronic obstructive pulmonary disease: a short- and long-term analysis. Arch Phys Med Rehabil 1990; 71: 570-573.

• Swerts PM, Mostert R, Wouters EF. Comparison of corridor and treadmill walking in patients with severe chronic obstructive pulmonary disease. Phys Ther 1990; 70: 439-442.

• ten Velde GP, Kuypers Engelen BT, Volovics A, Bosman FT. Examination of bone marrow biopsy specimens and staging of small cell lung cancer. Eur J Cancer 1990; 26: 1142-1145.

• Twijnstra A, Thunnissen FB, Lassouw G, Volovics A, Ten Velde GP. The role of the histologic subclassification of tumor cells in patients with small cell carcinoma of the lung and central nervous system metastases. Cancer 1990; 65: 1812-1815.

• Wesseling G, Vonk HM, Wouters EF. Effects of inhalation of beta 2-sympathicomi metic and anticholinergic agents on the impedance of the respiratory system in normal subjects. Chest 1990; 97: 1137-1140.

• Wesseling GJ, Vonk JM, Greve LH, Wouters EF. Dose effects of inhaled ipratropi um bromide on the impedance of the respiratory system in normal subjects. Int J Clin Pharmacol Ther Toxicol 1990; 28: 33-38.

• Wouters EF. Impedance measurement during air and He-O2 breathing before and after salbutamol in normal subjects. J Appl Physiol 1990; 69: 1665-1669.

• Wouters EF. Total respiratory impedance measurement by forced oscillations: a noninvasive method to assess bronchial response in occupational medicine. Exp Lung Res 1990; 16: 25-40.

• Wouters EF, Lándsér FJ, Polko AH, Visser BF. Density dependence of respiratory input impedance in normal subjects. Clin Exp Pharmacol Physiol 1990; 17: 477-484.

• Wouters EF, Mostert R, Polko AH, Visser BF. Forced expiratory flow and oscillo metric impedance measurement in evaluating airway obstruction. Respir Med 1990; 84: 205- 209.

1989

• Brutel de la Riviere T, Daniels Bosman MS, ten Velde GP. Two different dosages of ciprofloxacin in patients with respiratory tract infections. Pharm Weekbl Sci 1989; 11: 121- 123.

• Dentener MA, Greve JW, Maessen JG, Buurman WA. Role of tumour necrosis factor in the enhanced sensitivity of mice to endotoxin after exposure to lead. Immunophar macol Immunotoxicol 1989; 11: 321-334.

• Schols A, Mostert R, Soeters P, Greve LH, Wouters EF. Inventory of nutritional status in patients with COPD. Chest 1989; 96: 247-249.

• Schols AM, Mostert R, Soeters PB, Greve LH, Wouters EF. Nutritional state and exercise performance in patients with chronic obstructive lung disease. Thorax 1989; 44: 937-941.

• Schrikker AC, de Vries WR, Zwart A, Luijendijk SC. The excretion of highly soluble gases by the lung in man. Pflugers Arch 1989; 415: 214-219.

• Schrikker AC, de Vries WR, Zwart A, Luijendijk SC. The sloping alveolar plateau of tracer gases washed out from mixed venous blood in man. Pflugers Arch 1989; 413: 516- 522.

• Schrikker AC, de Vries WR, Zwart A, Luijendijk SC. Diffusion-limited gas mixing in the lung and its consequences for transpulmonary gas transport. Pflugers Arch 1989; 413: 523-527.

• ten Velde GP, Schutte B, Reijnders MM, Bosman FT, Blijham GH. Cytokinetic analysis of lung cancer by bromodeoxyuridine labeling of cytology specimens. Cytometry 1989; 10: 807-810.

• Wouters EF, Polko AH, Visser BF. Response localization of the pharmacological agents histamine and salbutamol along the respiratory system by forced oscillations in asthmatic subjects. J Asthma 1989; 26: 185-193.

• Wouters EF, Quaedvlieg M, Mostert R, Polko AH, Visser BF. Localization of bronchial response to ipratropium bromide by respiratory impedance measurement in asthmatics. Int J Clin Pharmacol Ther Toxicol 1989; 27: 145-149.

• Wouters EF, Verschoof AC, Polko AH, Visser BF. Impedance measurements of the respiratory system before and after salbutamol in COPD patients. Respir Med 1989; 83: 309- 313.

1988

• Luijendijk SC, Kelly G, Trippenbach T. Transpulmonary pressure and phrenic activity in early inspiration. Eur J Appl Physiol 1988; 58: 208-213.

• Luijendijk SC, Milic Emili J. Breathing patterns in anesthetized cats and the concept of minimum respiratory effort. J Appl Physiol 1988; 64: 31-41.

• ten Velde GP, Schutte B, Vermeulen A, Volovics A, Reynders MM, Blijham GH. Flow cytometric analysis of DNA ploidy level in paraffin-embedded tissue of non-small-cell lung cancer. Eur J Cancer Clin Oncol 1988; 24: 455-460.

• Verschoof AC, Ten Velde GP, Greve LH, Wouters EF. Thoracoscopic pleurodesis in the management of spontaneous pneumothorax. Respiration 1988; 53: 197-200.

• Wesseling GJ, van den Berg BW, Kortlandt JG, Greve LH, Ten Velde GP. Superior vena caval syndrome due to substernal goitre. Eur Respir J 1988; 1: 666-669.

• Wouters EF, Lándsér FJ, Polko AH, Visser BF. Physiological analysis of extended- spectrum oscillometry. Respiration 1988; 54: 263-270.

• Wouters EF, Polko AH, Schouten HJ, Visser BF. Contribution of impedance measurement of the respiratory system to bronchial challenge tests. J Asthma 1988; 25: 259- 267.

1987

• Borm PJ, Bast A, Wouters EF, Slangen JJ, Swaen GM, De Boorder TJ. Red blood cell anti-oxidant parameters in healthy elderly subjects versus silicosis patients. Free Radic Res Commun 1987; 3: 117-127.

• Schrijver M, Havenith MG, Hupperets PS, Greve LH, Wouters EF. Endobronchial non-Hodgkin lymphoma: report of two cases. Respiration 1987; 52: 228-231.

• ten Velde GP, Greve LH, Blijham GH. Cisplatin and cytarabine combination chemotherapy of advanced non-small cell lung cancer: a pilot study. Eur J Cancer Clin Oncol 1987; 23: 581-582.

• Twijnstra A, Boon PJ, Lormans AC, ten Velde GP. Neurotoxicity of prophylactic cranial irradiation in patients with small cell carcinoma of the lung. Eur J Cancer Clin Oncol 1987; 23: 983-986.

• van Luijtelaar EL, van der Grinten CP, Blokhuis HJ, Coenen AM. Sleep in the domestic hen (Gallus domesticus). Physiol Behav 1987; 41: 409-414.

1986

• Borm PJ, Bast A, Wouters EF, Slangen JJ, Swaen GM, de Boorder T. Red blood cell anti-oxidant parameters in silicosis. Int Arch Occup Environ Health 1986; 58: 235-244.

• Linssen GC, Bosman FT, Ten Velde GP. Histopathological subclassification of small cell carcinoma of the lung. Evaluation of its prognostic significance. Neth J Med 1986; 29: 313-317.

• Rombout JH, van der Grinten CP, Binkhorst FM, Taverne Thiele JJ, Schooneveld H. Immunocytochemical identification and localization of peptide hormones in the gastro- entero-pancreatic (GEP) endocrine system of the mouse and a stomachless fish, Barbus conchonius. Histochemistry 1986; 84: 471-483.

• ten Velde GP, Wouters EF, Greve LH, Vermeulen A, Keijser AH, Blijham GH. Alternating chemotherapy, prophylactic cranial irradiation and late local thoracic irradiation for small-cell lung cancer. Respiration 1986; 49: 216-221.

• Verschoof AC, Wouters EF, Greve LH. Bronchopulmonary carcinoid tumors. Neth J Surg 1986; 38: 109-111.

• Wiersma J, van de Heijning BJ, van der Grinten CP. Electrophysiological evidence for a sex difference in neural regulation of prolactin secretion in rats. Neuroendocrinology 1986; 44: 475-482.

• Wouters EF, Oei TK, Soeters PB, Havenith MG, Van Engelshoven JM, Greve LH. The value of computed tomography to the staging of non-small-cell primary bronchogenic carcinoma: a prospective study. Neth J Surg 1986; 38: 167-170.

• Zin WA, Behrakis PK, Luijendijk SC, Higgs BD, Baydur A, Boddener A, Milic Emili J. Immediate response to resistive loading in anesthetized humans. J Appl Physiol 1986; 60: 506-512.

• Zwart A, Luijendijk SC, de Vries WR. Excretion-retention data of steady state gas exchange in tidal breathing. I. Dependency on the blood-gas partition coefficient. Pflugers Arch 1986; 407: 204-210.

• Zwart A, Luijendijk SC, de Vries WR. Excretion-retention data of steady state gas exchange in tidal breathing. II. Dependency on the diffusion coefficient. Pflugers Arch 1986; 407: 211-215.

1985

• van der Kooij AM, Luijendijk SC. Longitudinal dispersion of gases measured in a model of the bronchial airways. J Appl Physiol 1985; 59: 1343-1349.

• Schrikker AC, de Vries WR, Zwart A, Luijendijk SC. Uptake of highly soluble gases in the epithelium of the conducting airways. Pflugers Arch 1985; 405: 389-394.

• Wouters EF, Greve LH. Inflammatory pseudotumours of the lung. Neth J Surg 1985; 37: 60-64.

• Wouters EF, Hupperts RM, Vreeling FW, Greve LH, Janevski B, Willebrand D, Berfelo WF. Successful treatment of tuberculous brain abscess. J Neurol 1985; 232: 118-119.

1984

• ten Velde GP, Kreukniet J. The histamine inhalation provocation test and its reproducibility. Respiration 1984; 45: 131-138.

• Wouters EF, Havenith MG, Vermeulen A, Greve LH. Malignant mesothelioma presenting in the pleura and peritoneum. Neth J Med 1984; 27: 213-217.

• Zocchi L, Luijendijk SC, Zin WA, Rossi A, Milic Emili J. Effect of resistive loading on inspiratory work output in anesthetized cats. J Appl Physiol 1984; 57: 839-849.

1983

• Luijendijk SC. Within-breath PCO2 levels in the airways and at the pulmonary stretch receptor sites. J Appl Physiol 1983; 55: 1333-1340.

• Oei TK, Wouters EF, Visser R, van Engelshoven JM, Greve LH. The value of conventional radiography and computed tomography (CT) in diagnosis of pulmonary hamartoma. Rontgenblatter 1983; 36: 324-327.

• Wouters EF, Greve LH. A rare case of hemoptysis. A short report. ROFO Fortschr Geb Rontgenstr Nuklearmed 1983; 139: 105.

• Zwart A, Luijendijk SC, de Vries WR. Expiratory and arterial partial pressure relations under different ventilation-perfusion conditions. J Appl Physiol 1983; 54: 1745- 1753.

1982

• Visser BF, Luijendijk SC. Gas mixing in the small airways, described by old and new models. Eur J Respir Dis Suppl 1982; 121: 26-35.

• de Vries WR, Luijendijk SC. Shape of single-breath washout curves of gases with different diffusion coefficients and blood solubilities. Bull Eur Physiopathol Respir 1982; 18: 215-227.

• de Vries WR, Luijendijk SC, Zwart A. Inert tracer gas washout from mixed venous blood: the sloping alveolar plateau. Respir Physiol 1982; 50: 283-297.

• Wouters EF, Oei TK, Van Engelshoven JM, Lemmens HA, Greve LH. Evaluation of the contribution of computed tomography to the staging of non-oat-cell primary bronchoge nic carcinoma. A retrospective study. ROFO Fortschr Geb Rontgenstr Nuklearmed 1982; 137: 540-543.

• Zwart A, Jansen JR, Luijendijk SC. Bohr dead space during helium washout. Bull Eur Physiopathol Respir 1982; 18: 261-272.

• Zwart A, Luijendijk SC. Excretion-retention diagram to evaluate gas exchange properties of vertebrate respiratory systems. Am J Physiol 1982; 243: R329-338.

1981

• Luijendijk SC, Zwart A, van der Kooij AM, de Vries WR. Evaluation of alveolar amplitude response technique for determination of lung perfusion in exercise. J Appl Physiol 1981; 50: 1071-1078.

• Van Hees PA, Van Lier HJ, Van Elteren PH, Driessen M, Van Hogezand RA, Ten Velde GP, Bakker JH, Van Tongeren JH. Effect of sulphasalazine in patients with active Crohn's disease: a controlled double-blind study. Gut 1981; 22: 404-409.

• de Vries WR, Luijendijk SC, Zwart A. Helium and sulfur hexafluoride washout in asymmetric lung models. J Appl Physiol 1981; 51: 1122-1130.

1980

• Luijendijk SC, Zwart A, de Vries WR, Salet WM. The sloping alveolar plateau at synchronous ventilation. Pflugers Arch 1980; 384: 267-277.